气体饱与溶液微粒形成技术制备布洛芬微粒.pdfVIP

气体饱和溶液微粒形成技术制备布洛芬微粒 陈 辉，赵磊。张辉贤，苏玉忠，王宏涛，李 军 (厦门大学化学工程与生物工程系。厦门361005) 摘要：采用气体饱和溶液微粒形成技术制备布洛芬微粒。实验考察预膨胀压力(10--一18MPa)、预膨胀温度 现。预膨胀温度升高，喷嘴直径变大，颗粒粒径变大；而预膨胀压力升高则粒径变小。 关键词：超临界流体；微粒，布洛芬}PGSS 028．8 中图分类号：TQ 文献标识码：A Formationfrom Particle lbuprofen Gas—SaturatedSolutions CHENHui，ZHAOLei，ZHANGHuixian，SU Jun。 Yuzhong，WANGHongtao，LI ChemicalandBiochemical andChemical (Departmentof Engineering，CollegeofChemistry 361005，P．R．China) Engineering，XiamenUniversity，Xiamen，F酊Jan micronizationof viaParticlesfromGas-Saturated was Abstract：The Ibuprofen studiedinthis werecarriedouttO theeffectofthe work．Experiments investigate pre-expansion nozzle thesizeand of diameter(60～120肛m)onmorphology 18MPa)，pre-expansiontemperature(50～70℃)and the were Electron precipitatedIbuprofenparticles．TheparticlesanalyzedbyusingScanning Microscopy sizeof aftermicronizationviathePGSS isbe- (SEM)and mean process SigmaScan．Theparticle Ibuprofen tween and the conditionsused．Resultsshowthatthe sizein— 2ttm 3btmdependinguponexperimental particle the andnozzlediameter in creases the of and，increase followingincreasingpre-expansiontemperature pressure can reducethemean size． slightly part