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含高剂量 CD34+细胞的非血缘脐血移植治疗 AMLMDS 后原发植入失败.pdf
第5 卷 第6期 器官移植 Vol5 No6
2014年11 月 Organ Transplantation Nov2014
·临床研究 ·
Primary graft failure following unrelated cord blood
+
transplantation with highdose ofCD34 cells
in the treatment ofAML/MDS
LuXiaoxi,Wan Zhi,Ma Zhigui,Gao Ju,Zhu Yiping
【Abstract】 Objective To analysis the cause of primary graft failure of unrelated cord blood
+
transplantation with highdose ofCD34 cellsintreatmentofacute myelocytic leukemia (AML)/myelodysplastic
syndrome (MDS)Methods A 4yearold girl was diagnosed AML/MDS at the Department of Pediatric
Hematology and Oncology of West China Second University Hospital of Sichuan UniversityShe presented
completely remission after induction and consolidation chemotherapyShe received unrelated partially human
leukocyte antigen (HLA)mismatched cord blood transplantationWe investigated the treatment outcomes of
UCBT and associated complicationsResults The patient suffered primary graft failure and then received
secondary haploidentical hematopoietic stem cell transplantation (HSCT)from hermotherHowever,she suffered
fatal multiresistant Acinetobacter spp septicemiaShe died due to respiratory failure on 7 d after the second
+
transplantationConclusions In this case,hematopoietic stem cells with high dose of CD34 cells could not
overcome the risk ofprimarygraftfailure and HLA disparityThepatientsprimarygraftfailurewasassociatedwith
platelet transfusion refractoriness and potent immunologic dysfunction,especially the antiHLA donor specific
antibo
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