含高剂量 CD34+细胞的非血缘脐血移植治疗 AMLMDS 后原发植入失败.pdfVIP

含高剂量 CD34+细胞的非血缘脐血移植治疗 AMLMDS 后原发植入失败.pdf

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含高剂量 CD34+细胞的非血缘脐血移植治疗 AMLMDS 后原发植入失败.pdf

第5 卷 第6期 器官移植 Vol5 No6 2014年11 月 Organ Transplantation Nov2014 ·临床研究 · Primary graft failure following unrelated cord blood + transplantation with highdose ofCD34 cells in the treatment ofAML/MDS LuXiaoxi,Wan Zhi,Ma Zhigui,Gao Ju,Zhu Yiping    【Abstract】 Objective To analysis the cause of primary graft failure of unrelated cord blood + transplantation with highdose ofCD34 cellsintreatmentofacute myelocytic leukemia (AML)/myelodysplastic syndrome (MDS)Methods A 4yearold girl was diagnosed AML/MDS at the Department of Pediatric Hematology and Oncology of West China Second University Hospital of Sichuan UniversityShe presented completely remission after induction and consolidation chemotherapyShe received unrelated partially human leukocyte antigen (HLA)mismatched cord blood transplantationWe investigated the treatment outcomes of UCBT and associated complicationsResults The patient suffered primary graft failure and then received secondary haploidentical hematopoietic stem cell transplantation (HSCT)from hermotherHowever,she suffered fatal multiresistant Acinetobacter spp septicemiaShe died due to respiratory failure on 7 d after the second + transplantationConclusions In this case,hematopoietic stem cells with high dose of CD34 cells could not overcome the risk ofprimarygraftfailure and HLA disparityThepatientsprimarygraftfailurewasassociatedwith platelet transfusion refractoriness and potent immunologic dysfunction,especially the antiHLA donor specific antibo

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