Tei指数评价心肌缺血再灌注家兔左心功能的研究.doc

Tei指数评价心肌缺血-再灌注家兔左心功能的研究 　　作者：张蓓， 秦际德， 何艳， 沈正， 刘兴德 作者单位：(贵阳医学院附院 心血管科， 贵州 贵阳 550004) 　　【摘要】 目的： 探讨Tei指数评价心肌缺血-再灌注家兔左心功能的价值。方法： 16只家兔随机分为2组，假手术组和缺血再灌注组; 180 min后对2组家兔行心脏超声检查，测量家兔左心室Tei指数、射血分数(EF)及左室短轴缩短率(FS)等指标;取各组家兔血清测超氧化物歧化酶(SOD)和丙二醛(MDA)。结果： 2组Tei指数、EF及FS比较均有显著性差异(P0.05) ,血清SOD及MDA测定结果差异亦有统计学意义(P0.05)。结论： 应用Tei指数可较好地评价心肌缺血-再灌注家兔左心功能的改变。 　　【关键词】 Tei指数; 心肌再灌注损伤; 超氧化物歧化酶; 丙二醛; 兔 　　Application of Tei Index in Evaluation of Ventricular Function of Rabbits after Ischemic Reperfusion 　　ZHANG Bei， QIN Jide， HE Yan, SHEN Zheng, LIU Xingde 　　(Department of Cardiovascular Medicime the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou, China) 　　[Abstract] Objective: To explore the value of Tei index in evaluation of left ventricular function of rabbits after ischemic reperfusion. Methods： Sixteen rabbits were divided into 2 groups randomly (8 in each): sham operation group (group S) and ischemia reperfusion (R/I) group (group R). Rabbits′ hearts were checked by ultrasonography and heart function was detected by monitoring of Tei, ejection fractino (EF), and fractional shortening (FS) of left ventricular in 180min after reperfusion. Enzymatic dynamics of myocardimn SOD and MDA in serum of these rabbits were detected. Results： There were significant differences of Tei, EF, and FS between the two groups (P0.05). The serum SOD level of group S was lower than that of group R, and the serum MDA level of group S was higher than that of group R. The differences were significant. Conclusion： Tei index is helpful in evaluation of rabbit cardiac function after ischemical reperfusion. 　　[Key words] Tei index; myocardial reperfusion injury; superoxide dismutase malondialdehyde; rabbits 　　急性心肌梗死患者的最佳处理就是尽快实施缺血心肌再灌注，但在恢复心肌再灌注后会发生心肌缺血再灌注损伤(ischemia/reperfusion injury，I/R)，导致恢复血供的缺血心肌细胞产生功能障碍及结构破坏，严重影响患者的预后。因此，积极寻找有效评估再灌注心肌心功能的指标具有着重要的临床意义。Tei指数作为较新的评价心脏整体功能的指标，被认为具有简便和敏感性好的优势。2008年6月～2008年10月对家兔心肌缺血再灌注损伤模型进行左心功能评价及血清SOD和MDA检测，结合血清SOD和MDA