四逆汤的药动学研究.pdfVIP

2002 10 中成 药 Oct. , 2002 24 10 Chinese Traditional Patent Medicine Vol. 24 No. 10 四逆汤的药动学研究 1 2 1 1 李 锐, 晏亦林, 周莉玲, 周玖瑶 ( 1. 广州中医药大学, 广东 广州510405; 2. 广州汉方现代中药研究开发有限公司, 广东 广州5 10240) : ; ; ; : : ( , , , ) , : , ( NO) , : , , K K T T , I/ 2 I/ 2 , , : : R285 : A : 1001- 1528( 2002) 10-0777-04 Pharmacokinetical study on Sini Decoction 1 2 1 1 LI Rui , YAN Y-i lin , ZHOU L-i lin , ZHOU Jiu-yao ( 1 Guangz hou Univ ersity of TCM ; 2 Gua ngz hou H anf ang M odern Natural M edicine R esearch and Dev elo ment Co. L td. Guangz hou, 510240 , China) Key words: Sini Decoction; pharmacokinetics; aconite alkaloid; nitric ox ide Abstract: Objective: To study the correlation of pharmacokinetics( PK) and pharmacodynamics( PD) of Sini De- coction ( SND) ( Radix Aconiti Praeparata, Rhizoma Zin iberis, Radix Glycyrrhizae, etc. ) and reveal the com- patibility of SND. Methods: Usin the dru serums from the same source, we determined the plasma concentra- tion in vivo in do and the pharmacolo ical effects at the same time inspected by the contents of aconitine-type alkaloids and nitric ox ide ( NO) . Results: The data of PK and PD can be both described by one compartment open model w ith first order absorption in vivo in do and the parameters of tw o methods are similar. The results show that the effective fraction of SND ives a prompt and lastin effect in accordance w ith characteristic func- tion of SND. Conclusion: A ood correlation ex ists in SND of the parameters between pharmacokinetics and pharmacodynamics. , , 1. 2 仪器 LC- 10A , ; [ 1] ,