蒙药作用机制研究新方法的探索.pdfVIP

中国医药导报 2015年4月第 12卷第 11期 窑综 述 窑 蒙药作用机制研究新方法的探索 斯 琴 房 君 敖登其木格 内蒙古自治区国际蒙医医院袁内蒙古呼和浩特 010065 [摘要]本文将试图寻找结合与现代生物学技术的蒙药作用机制研究的新方法遥根据目前的蒙药作用机制研究方 法和现代药物研究方法的需求袁整理微小核糖核酸渊microRNA袁miRNA冤相关文献袁分析miRNA在蒙药作用机制 研究中的应用可能性遥结果显示袁miRNA不但可以作为治疗和蒙药干预的一类新的体内作用靶标袁也可以作为蒙 药的一种活性分子在蒙药作用机制研究中发挥作用遥如果能够把miRNA相关技术充分应用于本领域袁从技术开 发的角度解决蒙药作用机制研究的实验设计关键之处与难点袁既能够扩展miRNA本身的应用范围袁又对蒙药现 代化和走向世界具有重要意义遥本研究提示和建议蒙药学研究领域学者对miRNA开展深入的验证实验袁为蒙医 药学的发展提供新的科学依据遥 [关键词] 蒙药曰多靶点曰作用机制曰新方法曰微小核糖核酸 [中图分类号] R291.2 [文献标识码]A [文章编号] 1673-7210渊2015冤04渊b冤-0027-03 Research for a new approach for studying the mechanism of Mongolian medicine Siqin FANG Jun Aodengqimuge International Mongolian Hospitalof Inner Mongolia,Inner MonggolAutonomous Region,Huhhot 010065, China [Abstract]This review summarizes the microRNA (miRNA) literatures, based on the method demands of both current studies on the mechanism of Mongolian medicine and modern medicine, analyzes the application possibility of miRNA on the research of the mechanism of Mongolian medicine, and explores a new research technique for studying the mechanism of Mongolian medicine, by combining modern biological technology. The results show that miRNA plays a critical role in the study of the mechanism of Mongolian medicine, not only as a new functional target for therapeutic, but also as an effective molecule of Mongolian medicine. It would expand the scope of miRNA application itself and of great importance for the modernization and globalization of Mongolian medicine, if miRNA-related technology can be sufficiently employed in this field, and resolve the key point and difficulties in the design of experiments. We advise more Mongolian medicine researchers to carry out further experiments of miRNAs to