聚乙二醇修饰对羟喜树碱隐形纳米囊泡的肿瘤靶向与抑瘤作用的影响_施斌.pdfVIP

·46 · 　　CHINESE JOURN L OF CLINIC L PH RM CY　2006 15 1 　 聚乙二醇修饰对羟喜树碱隐形纳米囊泡的肿瘤靶向和抑瘤作用的影 响＊ 施　斌, 方　超, 游美羡, 裴元英　(复旦大学药学院药剂学教研室, 上海200032) 【】　目的　(HCPT)(PEG- PHDC )S180 。方法　60 PEG-PHDC , HCPT PEG-PHDC , S180 。 结果　PEG 2 000、5 000、 125 10 000PEG-PHDC S180 I-HCPT UCHCPT 9.21、13.82、9.48 ;S180 88%、97.1%、80.8%, PHDC 41.8, 17.3%。结论　PEG PEG , PEG 5 000, 80 nm , HCPT 。 【】　;　;　 【】R979.14　　　【】 　　　【】1007-4406(2006)01-0046-04 Tumor targeting effect and anti-tumor activity of hydroxycamptothecin loaded stealth niosomeswith different polyethylene glycol chain length Shi Bin, Fang Chao,You Meixian, Pei Yuanying　(Department of Pharmaceutics, Schoolof Pharmacy, Fudan Univer- sity, Shanghai 200032, China) 【ABSTRACT】　AIM 　To investigate the tumor targeting effect and anti-tumor activity of hydroxycamptothecin (HCPT) loaded poly (methoxy-polyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate)(PEG-PHDC )niosomes with dif- ferent polyethylene glycol (PEG)chain length.METH DS 　Stealth PEG-PHDC niosomes were prepared with span60 and PEG-PHDC acting as drug carrier.S180 tumor bearing mice were used for biodistribution test and anti-tumor test. RESULTS 　Niosomes with PEG chain length of 2 000, 5 000, 10 000 showed an obvious tumor targeting effect, with UC in tumor increasing by 9.21, 13.82 and 9.48-fold, respectively, compared with HCPT.The tumor inhibition rate of niosomes with PEG chain length of 5 000, 2 000, 10 000 were 88%, 97.1%, 80.8%, respectively, while HCPT had only 17.3%inhibition rate.C NCLUSI N 　PEG-PHDC niosomes have a better anti-tumor effect than HCPT and PHDC niosomes.Under this experimental conditions, PEG-PHDC niosomeswith PEG chain length of 5 000and parti- cle size of 80 nm have themost significant tumor targeting effect. 【KEY W RDS】　hydroxycamptothecin;　niosome;　tumor targeting 　　[Poly ,、, (methoxy-polyethyleneglycol cyanoacrylate-co-n-h