COPD患者血清淀粉样蛋白A变化及意义.pdfVIP

安徽医学 第3l卷第4期 Anhui Medical 2010年4月 316 Journal COPD患者血清淀粉样蛋白A变化及意义 杨瑞青刘 斌郑法德周瑞清赵军 [摘要] [关键词]肺疾病；阻塞性；血清淀粉样蛋白A；C反应蛋白 doi：10．39690．issn．1000-0399．2010．04．006 inserum Alevelanditsclinical in with obstructive disease chronic Changes amyloid significancepatients pulmonary nl Fade,et yangRuiqing,LiuBin，Zheng 236003，China DepartmentofRespiratory，FuyangPeoplesHospital，Fuyang To the andclinical ofseFum A(SAA)levelsin withchronicob- [Abstract]Objectivechanges significance explore amyloid patients structive disease(COPD)．MethodsBlood in withCOPDboth acuteexacerbationandstable were pulmonary samplespatients during stage volunteerswereenrolledascontrols．ThelevelsofserumSAA、CRP、TNF-aandIL-8weremeasured collected．Healthy by levelsofSAAandCRPin withAECOPDwere thanthosein withCOPD stable andinthe The patients significantlyhigher patients during stage levelsofSAAin withCOPD stable were thanthoseinthe controls(PO．01)．Thepatients during stage significantlyhigher controls(PO．Oi)；serum SAAlevelshad correlationswithTNF-aand CRPlevelshad correlationswithTNF-aand IL-8(r--0．76；r--0．71)．serum significantly significantly areasunderROCcurveofserumSAAto AECOPDWas0．837：t-0．066．thoseofserumCRPWas0．751：tO．049． IL一8(r=o．69；r=0．63)；The diagnose Con