Tight regulation of p53 activity （2012，有很多染色的介绍！！）外文翻译.pdfVIP

Developmental Biology 353 (2011) 354–366 Contents lists available at ScienceDirect Developmental Biology jour nal homepage: /developmentalbiology Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching Sylvia Hilliard, Karam Aboudehen, Xiao Yao, Samir S. El-Dahr ⁎ Tulane University School of Medicine, Department of Pediatrics, Section of Pediatric Nephrology, New Orleans, LA, USA a r t i c l e i n f o a b s t r a c t Article history: Mdm2 (Murine Double Minute-2) is required to control cellular p53 activity and protein levels. Mdm2 null Received for publication 25 October 2010 embryos die of p53-mediated growth arrest and apoptosis at the peri-implantation stage. Thus, the absolute Revised 10 March 2011 requirement for Mdm2 in organogenesis is unknown. This study examined the role of Mdm2 in kidney Accepted 11 March 2011 development, an organ which develops via epithelial–mesenchymal interactions and branching morpho- Available online 21 March 2011 genesis. Mdm2 mRNA and protein are expressed in the ureteric bud (UB) epithelium and metanephric mesenchyme (MM) lineages. We report here the results of conditional deletion of Mdm2 from the UB Keywords: Ureteric bud epithelium. UBmdm2 −/ − mice die soon after birth and uniformly display severe renal hypodysplasia due to Mdm2