竞争性内源RNA的生物学功能及其调控.pdfVIP

Hereditas (Beijing) 2015 年 8 月, 37(8): 756 ―764 综 述 竞争性内源RNA 的生物学功能及其调控 1,2 1,2 1,2 1,2 1,2 李静秋 ，杨杰 ，周平 ，乐燕萍 ，龚朝辉 1. 宁波大学医学院生物化学与分子生物学研究所，宁波 315211 ； 2. 浙江省病理生理学技术研究重点实验室，宁波 315211 摘要 : 最新研究表明，RNA 之间可以通过竞争结合共同的 microRNA 反应元件(microRNA response element, MRE) 实现相互调节，这种调控模式构成竞争性内源 RNA(Competing endogenous RNA, ceRNA) 。已发现 的ceRNA 包括蛋白编码mRNA 和非编码RNA ，其中后者包括假基因转录物、长链非编码RNA(Long non-coding RNA, lncRNA) 、环状RNA(Circular RNA, circRNA)等。文章主要从ceRNA 分类的角度，阐述各类ceRNA 构成 的调控网络发挥的生物学功能在病理和生理相关过程中的作用，以及可能影响ceRNA 调控有效性的因素。 关键词 : 竞争性内源RNA ；微RNA 反应元件；假基因；长链非编码RNA；环状RNA The biological functions and regulations of competing endogenous RNA Jingqiu Li1,2, Jie Yang1,2, Ping Zhou1,2, Yanping Le1,2, Zhaohui Gong1,2 1. Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China; 2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China Abstract: Recent studies demonstrate that RNA species could regulate each other by competing for shared microRNA response elements (MREs). This regulatory model is called competing endogenous RNA (ceRNA). Cur- rently, the identified ceRNAs cover coding and non-coding RNAs. The latter includes pseudogene transcripts, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and so on. In this review, we summarize the biological functions of regulatory networks consisting of various types of ceRNAs and their roles in the pathological and physi- ological processes. Additionally, several factors that may regulate ceRNAs were discussed . Keywords: competing endogenous RNA; microRNA response element; pseudogene; long non-coding RNA; circular RNA 收稿日期: 2015−02−09; 修回日期: 2015−04−07 基金项目: 浙江省自然科学基金项目(编号：LY15C060003) ，浙江省