Programmed deep brain stimulation synchronizes VTA gamma band field potential and alleviates depressive-like behavior in rats》.pdf

Neuropharmacology 91 (2015) 135e141 Contents lists available at ScienceDirect Neuropharmacology journal homepage: /locate/neuropharm Programmed deep brain stimulation synchronizes VTA gamma band field potential and alleviates depressive-like behavior in rats a, 1 a, 1 b, 1 b a Tomer Gazit , Alexander Friedman , Elad Lax , Merav Samuel , Roy Zahut , Moshe Katz a, Lital Abraham b, Hadass Tischler a, Mina Teicher a, Gal Yadid a, b, * a The Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, 52900, Ramat-Gan, Israel b The Mina Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel a r t i c l e i n f o a b s t r a c t Article history: Deep brain stimulation (DBS) significantly alleviates symptoms in various neurological disorders. Current Received 7 July 2014 research focuses on developing programmed stimulation protocols for customization to individual Received in revised form symptoms. However, the therapeutic mechanism of action of programmed DBS (pDBS) is poorly un- 30 November 2014 derstood. We previously demonstrated that pDBS in the ventral tegmental area (VTA) normalizes mo- Accepted 1 December 2014 Available online 11 December 2014 lecular and behavioral abnormalities in the Flinders Sensitive Line (FSL) rat model for depression. Herein,