Prothrombin G20210A mutation is associated with recurrent pregnancy loss A systematic review and meta-analysis update》.pdf

Thrombosis Research 135 (2015) 339–346 Contents lists available at ScienceDirect Thrombosis Research jour nal homepage: www.el sevie r. com/ locate/ thromres Regular Article Prothrombin G20210A mutation is associated with recurrent pregnancy loss: A systematic review and meta-analysis update Hui Gao a, Fang-biao Tao a,b,⁎ a Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 18 Meishan Road, Hefei (230032), Anhui, China b Anhui Provincial Key Laboratory of Population Health Aristogenics, Hefei (230032), China a r t i c l e i n f o a b s t r a c t Article history: Background: Thrombophilia is reported to be a candidate etiology of recurrent pregnancy loss (RPL). No Received 7 July 2014 conclusive results on the association between prothrombin G20210A mutation and RPL have been reported. Received in revised form 30 November 2014 Methods: We undertook a systematic review and meta-analysis of 37 case-control studies using a comprehensive Accepted 1 December 2014 electronic search on papers published by May 2014. We studied 5400 cases and 4640 controls to investigate the Available online 5 December 2014 potential association between G20210A and RPL. In this review, we define RPL as more than 2 miscarriages. Results: A significant association was found between G20210A and RPL, with a combined odds ratio (OR) of 1.81 Keywords: