《Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers.》.pdf

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《Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers.》.pdf

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ChineseJournalofPolymers￡ieneeVo1．32No．8．(2014)．1111-1118 ChineseJournaloleomerScience ◎ChineseChemicalSociety InstituteofChemistry，CAS Springer—VerlagBerlinHeidelberg2014 PreventionofLocalLiverCancerRecurrenceafterSurgeryUsing M ultilayeredCisplatin-loadedPolylactideElectrospunNanofibers YanZhang十 ShiLiu’ct XueW ang，Zhi—yunZhang’c，Xia—binJing，， , PingZhang’and Zhi—gangXie。 TheFirstHospita ofJilinUniversitv,Changchun130021。China StateKeyLaboratoryofPolymerPhvsicSandChemistry,ChangchunInstituteofAppliedChemistry, ChineseAcademyofSciences，Changchun130022，China 。Th eUniversitYofChineseAeademyofSciences，Beoing100049，China 。HealthImprovingDepartment , China-JapanUnionHospitalofJilinUniversity,Changchun130033，China AbstractInthisstudyacisplatin．1oaded，multilayeredpolylactide(PLA)electrospunnanofibers，withthestructureoftwo layersofdrug—loadedmatbeingsandwichedbythreelayersofblankmat，weredesignedforprolongedcisplatinreleaseat surgicalmargm topreventlocalcancerrecurrenceofllowingsurgicalresection inamurlnemode1．InVlVOOrugreleaseand biodistributionstudy suggestedthatthemultilayeredfibrousmatdisplayedaslowercisplatinreleasebehaviorandamore stabledragrententioninthelocaltissuewithin24hthanthatofsingle—layeredfibrousmat．Bycoveringthesurgicalsitewith themultilayeredfibrousmatofllowingresectionofsubcutaneous1ivercancerinmice，retar