《Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo.》.pdf
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《Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo.》.pdf
JournalHomepage:
wwwjcimjourna1.corn/jim
www.elsevier.com/locate/issn
Availablealsoonlineatwww.sciencedirect.com.
Copyright@2014.JournalofIntegrativeMedicineEditorialoffice.
E-editionpublishedbyElsevier(Singapore)PteLtd.Allrightsreserved
≮j
●
Pristimerinenhancesrecombinantadeno—associated
ressioninhuman
● ● ■ ■ ■ 0 一 ■ ■ 0 一 一 ■ ■
ce¨llnesin vitroandm U¨nehepatocytes,n Wvo
Li.naWang’I213,YuanWang1,2,3,4YuanLu,zi-feiYin’,Yuan-huiZhang’,,。,George Aslanidi,
ArunSrivastavaI3I61 Chang-quanLing’ ChenLing,。
, ,
1.ChanghaiHospitalofTraditionalChineseMedicine.SecondM_litaryMedicalUniversity.Shanghai
200433.China
2.DivisionofCellularandMolecularTherapy.DepartmentofPediatrics,UniversityofFloridaCollegeof
Medicine,Gainesville Florida32611。USA
3.PowelIGeneTherapyCenter,UniversityofFloridaCollegeofMedicine,Gainesville,Florida32611,USA
4.ShanghaiUniversityofTraditionalChineseMedicine.Shanghai201203.China
5.DepartmentofOrthopaedicsandRehabiIitati0n,UniversityofFloridaCollegeofMedicine,Gainesville,
Florida32611.USA
6.DepartmentofMolecularGeneticsandMicrobiology,UniversityofFloridaCollegeofMedicine,Gainesville,
Florida32611.USA
7.Geneticslnstitute,UniversityofFloridaCollegeofMedicine,Gainesville.Florida32611,USA
8.ShandsCancerCenter,UniversityofFloridaCollegeofMedicine,Gainesville,Florida32611,USA
OBJECTlVE:lnthepresentstudy.we systemicallyevaluated theab_lity oftwobioactive
compoundsfrOm traditionaIChinesemedicine,celastrolandpristimerin.toenhancerecombinant
adeno.associatedvirus(rAAV)serotypevector-mediatedtransgeneexpressionbothinhuman
celllinesinvitr
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