白三烯A4水解酶基因多态性与中国人结核易感性的相关性研究.pdf

目 录 摘要······················-·········································1 Abstract····························································2 弓I言································································3 第一章(材料)·······················································喝 第一节(研究对象)···············································8 第二节(主要试剂与仪器设备)·····································喝 第二章(方法)·······················································10 第一节(标本采集)···············································10 第二节(DNA抽提及检测)···································-····10 第三章(数据统计分析)··············································13 第四章(实验结果)··················································14 第一节(研究对象的一般情况分析)···························-····14 第二节(LTA4H基因多态性位点的检测·····························14 第三节(基因测序结果与引物设计)·······························15 第四节(LTA4H5个多态性位点的信息)····························18 第五节(SNP分型结果)··········································18 第六节(对照组HwE分析)········································25 第七节(LTA4H5个多态性位点的等位基因分析)·····················．25 第八节(LTMH基因型分析)·······································26 第九节LTA4H基因连锁不平衡分析)································27 第五章(讨论)······················································29 第六章(结论)······················································32 参考文献················································-·········33 中英文对照表······················································36 综述·················-·············································38 致谢·························-····································49 万方数据 摘 要 白三烯A4水解酶基因多态性与中国人结核易感性的相关性研究 【背景】结核由结核分枝杆菌引起的传染性疾病，很多因素影响结核病的发生与 严重程度，包括环境和宿主基因因素。很多基因已经被确认与结核易感性密