《ZNF533、DOCK4和IMMP2L基因多态性与中国东北汉族孤独症的关联研究 Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population》.pdfVIP

264 Liang et al. / J Zhejiang Univ-Sci B (Biomed Biotechnol) 2014 15(3):264-271 Journal of Zhejiang University-SCIENCE B (Biomedicine Biotechnology) ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) /jzus; E-mail: jzus@ Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in * a northeastern Chinese Han population †1 1 1 1 1 1 Shuang LIANG , Xue-lai WANG , Ming-yang ZOU , Han WANG , Xue ZHOU , Cai-hong SUN , Wei XIA1 †‡1 2 2 , Li-jie WU , Takashi X. FUJISAWA , Akemi TOMODA 1 ( Department of Children’s and Adolescent Health, Public Health College of Harbin Medical University, Harbin 150081, China) (2Research Center for Child Mental Development, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Fukui 910-1193, Japan) †E-mail: liangyouyou2004@163.com; wulijiehyd@126.com Received May 8, 2013; Revision accepted Nov. 20, 2013; Crosschecked Feb. 23, 2014 Abstract: Objective: A study in a Caucasian population has identified two single-nucleotide polymorphisms (SNPs) in ZNF533, one in DOCK4, and two in IMMP2L, which were all significantly associated with autism. They are located in AUTS1 and AUTS5 , which have been identified as autism susceptibility loci in several genome-wide screens. The present study aimed to investigate whether ZNF533, DOCK4, and IMMP2L genes are also associated with autism in a northeaste