《Sleep-related hypoxemia aggravates systematic inflammation in emphysematous rats》.pdfVIP

7J：2392·2399 2392 ChinMedJ2010；123(1 article Original Sleep-relatedhypoxemiaaggravatessystematic in rats emphysematous FENG An-Po Qi，CHEN Jing，AmbroseChiang，WU Bao—yuan，CUILin—yang，LIANGDong—chun， ZHANGZe—liandYAoWb Keywords：sleep—related stress；bronchoalveolar hypoxemia；emphysema；inflammation；oxidativelavagefluid； superoxidedismutase；catalase；malondialdehyde disturbancejscommonin with aimedto anoveImodeJof BackgroundSleep patientsemphlysema．Thisstudy develop to the ofSRHIEin rats，and status sleep·relatedhypoxemia(SRH)inemphysema(SRHIE)withexploreinflammatory andwholeblood． lung，liver,pancreas，carotidarlery Methods maleWistarratswere to5 with15 tothe SevenW-five assignedgroups pergroupaccordingexposure conditions．Thevariedwiththe of and of caused protocols degreehypoxiaexposureseveritypre．existinqemphysemaby smoke smoke tosmoke cigaretteexposure：(1)SRHcontrol(SRHCtrl)group，shamexposure(smokeexposum，exposed 0f15 twice SRH total cigaretteseveryday,16weeks)andexposure(12．5％02，3hours，SRH hypoxia exposure，divide hoursor3 4 minutesor45 distributethese time(1．5 hours)intoperiodsevenly(22．5 minutes)and hypoxiaperiodsevenly