脑出血后认知障碍和中风中医辨证分型的关系探讨.pdfVIP

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2016-01-12 发布于安徽
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脑出血后认知障碍和中风中医辨证分型的关系探讨.pdf

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目录中文摘要 ···················································1 英文摘要 ···················································3 引言 ····················································6 正文 ····················································7 1.资料 ···················································7 1.1 相关标准 ·················································7 1.2 研究对象 ················································10 2.方法 ················································10 2.1 研究方法 ················································10 2.2 统计方法 ················································11 3.结果 ················································11 4.讨论 ················································15 5.存在的问题和展望 ······································21 结论 ··················································22 参考文献 ··················································23 附录 ··················································25 综述 ··················································27 致谢 ··················································36 攻读学位期间发表的学术论文目录 ·······················37 作者声明 ··················································38 个人简历 ··················································39 中文摘要目的:通过探索脑出血（Intracerebral Hemorrhage, ICH ）后认知障碍 (Cognitive Impairment ，CI)与中风中医辨证分型的关系，认识其发病机制和规律，为今后开展中医药对认知障碍的早期干预提供参考。方法:收集134 名脑出血患者，经头颅CT 及MRI 证实，通过简易精神状态量表测定分为认知障碍组 61 例与非认知障碍组 73 例。各组分别进行简易精神状态量表(Mini Mental State Examination ，MMSE)评测、事件相关电位（Event-related Potential, ERP ）-P300 检测、中医辨证分型。研究各部分指标与认知障碍的相关性，对脑出血后认知障碍与中医辨证分型的关系予以探讨。结果: 1. MMSE 评分:脑出血病人 MMSE 评分显著低于正常对照组 (P0.01) ，且脑出血后 CI 组 MMSE 评分显著低于脑出血后无 CI 组 (P0.01) 。2. ERP －P300 测定：脑出血后CI 组P300 潜伏期较脑出血后无 CI 组和正常对照组显著延长(P0.01) ，尽管脑出血后无CI 组的P300 潜伏期较正常对照组有所延长，但无统计学差异(P0.05) ，P300 波幅在正常对照组、脑出血后无 CI 组及脑出血后 CI 组依次降低，但