Dynamic Behavior and Function of Foxp^3＋ Regulatory T Cells in Tumor Bearing Host.pdfVIP

Cellular MolecularImmunology 3 Review DynamicBehaviorandFunctionofFoxp3+RegulatoryTCellsin TumorBearingHost EXiao．FengQin’ RegulatoryTcells(Tregs)expressingforkhead／winged-helixtranscriptionfactorFoxp3representadistinctlineage oflymphocyteswhichplayacentralrolein protectingthehostfrom autoimmunediseases．However,Trlegsalso poseamajorproblem toanti．tumorimmunity．Growingbodyofevidencefrom both laboratoryandclinical investigatiOnshasdemonstratedthatexpansionandaccumulationoftheseimmunosuppressivecellscorrelateswith advanced tumor growth and predicts poor disease prognosis．How tumor development subverts normal self-tolerancefunctionofn ．egstherebythwartshostanti-tumorimmunityremainselusive．Thisreview willdiscuss ourcurrentknowledgeinunderstandin2thedynamicsand plasticityofFoxp3 Tregactivationandinductionin tumorbearinghostsandtheirinteractionwithvariousantigenpresentingcellsfAPCs1intumormicroenvironment leadingtotheestablishmentofactivelocaland system icimmunesuppression．Cellular＆ MolecularImmunology． 2009；6(1)：3．13． KeyW ords：Treg，APC，tumormicroenvironment，immunesuppression，anti-tumorimmunity Introduction tumor-specificTregsto suppressthepriming na d effector function of tumor killing effector cells．Thus，immune surveillanceislragelyinefiectiveandestablishedtumorscan Themammalian immune system isevolved toprotectthe aggressively inhibitvaccination orothertreatmentsinduced hostfrom a diverse range of harmfulagents．including anti—tumorimmuneresponses．Emerging evidenceindicates tumors． However, malignna t tumors present a special