3-取代苄氧基-6-取代氨基哒嗪衍生物的合成及其除草活性有机化学.pdfVIP

2007 年第 27 卷 有 机 化 学 Vol. 27, 2007 第 12 期, 1530～1536 Chinese Journal of Organic Chemistry No. 12, 1530～1536 ·研究论文· 3-取代苄氧基-6-取代氨基哒嗪衍生物的合成及其除草活性 胡方中 张 敏 朱有全 邹小毛 刘 斌 杨华铮* (南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071) 摘要 通过 3-取代苄氧基-6-氟哒嗪 75～80 ℃与二甲胺的绝对无水乙醇溶液封管反应, 或在回流条件下分别与吗啡 啉或哌啶反应, 合成一系列新颖的 3-取代苄氧基-6-取代氨基哒嗪类化合物, 它们的结构均经 IR, 1H NMR 和元素分析确 证. 初步的除草活性测定结果表明, 该类化合物具有一定的除草活性, 讨论了它们的结构与除草活性的关系. 关键词 3-取代苄氧基-6-取代氨基哒嗪; 合成; 除草活性; 构效关系 Synthesis and Herbicidal Activity of 3-(Substituted benzyloxy)- 6-(substituted amino)pyridazines HU, Fang-Zhong ZHANG, Min ZHU, You-Quan ZOU, Xiao-Mao LIU, Bin YANG, Hua-Zheng* (State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071) Abstract A series of new 3-(substituted benzyloxy)-6-(substituted amino)pyridazines were synthesized through the reaction of 3-(substituted benzyloxy)-6-fluoropyridazines with the solution of dimethylamine in absolute ethanol in a sealed tube in 75～80 ℃ or with morpholine or piperidine under reflux, respectively. 1 The title compounds were identified by IR, H NMR spectra and elemental analyses. Preliminary bioassay showed that some of them had certain extent herbicidal activities, and the structure-activity relationship was also discussed. Keywords 3-(substituted benzyloxy)-6-(substituted amino)pyridazine; synthesis; herbicidal activity; structure- activity relatio