双功能手性硫脲催化的不对称Michael加成反应研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201402029 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 双功能手性硫脲催化的不对称Michael 加成反应研究进展 侯学会*,a 马志伟a,b 王建玲a 刘宏民*,c (a 河南牧业经济学院质检系 郑州 450011) (b 郑州大学化学与分子工程学院 郑州 450001) (c 郑州大学药学院 郑州 450001) 摘要 手性有机小分子催化是近年来不对称催化领域的一个热门研究课题. 其具有反应条件温和、环境友好等优点, 符合绿色化学的要求. 手性氨基-硫脲类催化剂, 特别是双功能的手性硫脲, 已经在众多的不对称反应中表现出了优秀 的催化性能. 主要综述了双功能手性硫脲在不对称 Michael 加成反应中的应用, 并对其前景及发展趋势作了展望. 关键词 有机催化; 双功能; 手性硫脲; Michael 加成 Rencent Advances in Asymmetric Michael Addition Catalyzed by Chiral Bifunctional Thioureas Hou, Xuehui*,a Ma, Zhiweia,b Wang, Jianlinga Liu, Hongmin*,c a ( Department of Quality Detection and Management, Henan University of Animal Husbandry and Economy, Zhengzhou 450011) (b College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001) c ( School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001) Abstract Asymmetric organocatalysis has been a frontier in the field of asymmetric catalysis. The comparable advantages, including mild reaction conditions, environment benign, and so on, render the organocatalytic reaction to possess some fea- tures of green chemistry. Chiral amino-thiourea organocatalyst, especially chiral bifunctional thiourea, has been shown excel- lent catalytic performance in a variety of asymmetric reactions.