基于罗丹明的重金属和过渡金属阳离子荧光分子探针研究进展有机化学.pdfVIP

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 7 期, 997～1010 Chinese Journal of Organic Chemistry No. 7, 997～1010 ·综述与进展· 基于罗丹明的重金属和过渡金属阳离子荧光分子探针研究进展 孙 伟 胡德禹 吴志兵 宋宝安 杨 松* (贵州大学精细化工研究开发中心 绿色农药与农业生物工程国家重点实验室培育基地 教育部绿色农药与生物工程重点实验室 贵阳 550025) 摘要 介绍了近五年来以罗丹明为母体的重金属和过渡金属阳离子荧光分子探针领域的研究进展. 文中按照荧光团和 识别基团之间连接臂的不同对国内外各研究组的工作进展进行归类总结, 并对探针设计的思路、探针的性质和应用给 出了简要介绍. 关键词 荧光探针; 金属离子; 罗丹明; PET(光诱导电子转移); FRET(荧光共振能量转移) Research Progress of Fluorescent Molecular Probes for Heavy and Transition Metallic Cations Based on Rhodamine Fluorophore Sun, Wei Hu, Deyu Wu, Zhibing Song, Baoan Yang, Song* (State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Bioengineering of Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025) Abstract The research progress of fluorescent molecular probes based on rhodamine fluorophore for heavy and transition metal cations during the past five years is reviewed. The fluorescent molecular probes are classified based on different spacer structure. And the probe design ideas, probe properties and their ap- plications are briefly introduced. Keywords fluorescent probe; metal cation; rhodamine; PET (photoinduced electron transfer); FRET (fluorescence resonance energy transfer) 重金属和过渡金属阳离子(HTMC)广泛的存在于自 罗丹明(Rhodamine)类荧光团具有荧光量子产率高、 然界中, 一些过渡金属离子(如 Cu2 ＋, Zn2 ＋等)在生命过 荧光性质可调控、对酸碱度的灵敏度低、荧光辐射波长