水-盐酸两步法分离瓜环混合物有机化学.pdfVIP

2007 年第 27 卷 有 机 化 学 Vol. 27, 2007 第 7 期, 880～884 Chinese Journal of Organic Chemistry No. 7, 880～884 ·研究简报· 水-盐酸两步法分离瓜环混合物 毕 强* 胡英鹏 杨 琴 马彩莲 李东亮 (西安建筑科技大学理学院 西安 710055) 摘要 根据各元瓜环在水和盐酸两种溶剂中溶解度的不同, 提出了一种通过水-盐酸两步分离混合瓜环的方法. 探讨 了溶剂用量、盐酸浓度等因素对分离效果的影响, 确定了最佳的分离工艺条件, 使 CB[5], CB[6], CB[7]和 CB[8] 的分离 产率分别达到 78.9%, 92.0%, 88.0%和 75.0%. 分离得到的瓜环单体经核磁共振检测, 纯度在 95% 以上, 其中 CB[5] 的纯 度达到 98%. 研究结果表明, 本工艺是一种简单有效的分离混合瓜环的方法. 关键词 瓜环; 分离; 核磁共振; 水-盐酸; 两步法 A Two-Step Approach for Cucurbit[n]uril Compound Separating by Water and Hydrochloric Acid BI, Qiang* HU, Ying-Peng YANG, Qin MA, Cai-Lian LI, Dong-Liang (School of Science, Xian University of Architecture and Technology, Xian 710055) Abstract This article developed a two-step separating approach of cucurbit[n]uril compound, which was based on the different solubility of cucurbit[n]uril in water and hydrochloric acid. Several factors of separat- ing were deliberated and the optimized separating conditions were fixed. The productivity of CB[5], CB[6], CB[7] and CB[8] is 78.9%, 92.0%, 88.0% and 75.0% respectively. The purity of cucurbit[n]uril is higher than 95% determined by NMR spectra. Especially for CB[5], the detected purity is up to 98%. The results proved the discussed method to be a simple and reliable CB[n] monomers separating process. Keywords cucurbit[n]uril; separating; nuclear magnetic resonance; water and hydrochloric acid; two-step approach 瓜环[1～4] 是超分子化学中继冠醚、环糊精、杯芳烃 而在分子识别、超分子催化以及分子组装等领域具有广 之后备受关注的一类新型笼状大环主体分子 . 早在 阔