How to Treat a Signal Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer.pdfVIP

SAGE-Hindawi Access to Research Journal of Thyroid Research Volume 2011, Article ID 678357, 10 pages doi:10.4061/2011/678357 Review Article How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer Hugo Prazeres,1, 2, 3 Joana Torres,1 Fernando Rodrigues,4 Joana P. Couto,1, 3 ˜ 1, 3, 5 ˜ 1, 3, 6 1, 3 Joao Vinagre, Manuel Sobrinho-Simoes, and Paula Soares 1 Cancer Biology Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal 2 Molecular Pathology Service, Portuguese Institute of Oncology of Coimbra FG, EPE, Avenida Bissaya Barreto, 98, 3000-075 Coimbra, Portugal 3 Department of Pathology, Faculty of Medicine of Porto University, Al. Prof. Hernani Monteiro, 4200-319 Porto, Portugal ˆ 4 Endocrinology Service, Portuguese Institute of Oncology of Coimbra FG, EPE, Avenida Bissaya Barreto, 98, 3000-075 Coimbra, Portugal 5 Abel Salazar Biomedical Sciences Institute (ICBAS), Lg. Prof. Abel Salazar, 4099-003 Porto, Portugal 6 Department of Pathology, Hospital Sao Joao, Al. Prof. Hernani Monteiro, 4200-319 Porto, Portugal ˜ ˜ ˆ Correspondence should be addressed to Paula Soares, psoares@ipatimup.pt Received 11 February 2011; Accepted 10 April 2011 ˜ Academic Editor: Maria Joao M. Bugalho Copyright © 2011 Hugo Prazeres et al. This is an open access article distributed under the Creative Com