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THE ROLE OF MUSCLE SPINDLE IN MUSCLE ATROPHY INDUCTED BY SIMULATED MICROGRAVITY.pdf
维普资讯
ACADJⅪTU2003，15(1)：25—29
唧 R0LE OFM USC1ESP]N【DLE IN M IJSC1E 玎 PHY INDUCED BY
SIⅣIIⅡATED Ⅷ CRoGRAⅥ TY
刁删呜Hongmei(~ ) ，FanXiaoli(樊小力)，ZhouJibin(周继斌)
DepartmentofPhysiology，MedicalSchoo!of ’arlJiaotongUniversity， ’口，z710061，China．
ABSTRACT：CYoie~-tivo Toeomlmretheo~ss-seefion糊 (CSA)andthet~ ammtivity0f=nlepted-e~ a
soleusextrafmalandinlrafusalfibersafter 咖山m _皿 l10哟 andtodmm stzmetherole0fmmeleslid e
mesdeatrophytltda~~ bysimulatedmic呻 钾．I tfIoc鸯 Tt-e 加咖珊由ist0吐旧 I怔chiqI (AeC)andh姆
m．alys蠹swerereedtoassessthecmjegated-ebiqe~n蛔柚加皿陷纽 j豫 andthe嘲 -sectional糊 0f Iand
exlxafesalfibers0fsolellsinsimulated-mi~ vityrals． 括 ①1I蚰．硼叩朗 m tamedal弼r曜阳|曩i lem0fs0-|爆
m盈心．MeanfiberCSAofextrafusalrtl~mw骶 (7±2)％，(21±4)％and(32±7)％~ lhaaf 3d 冒，7d町冒and
14days硼印a咖 ，r~ tivdy．WhiletheCAS0tiamafumifm懿 (b日g+c—ha—inf )were(14±3)％ (P
0．05)，(3O±7)％ (P0．01)and(44±10)％ (PO．01)蜘咽l蛔 after3adys，7ears硼 14出哆日期印哪 叫．
② inmaonoreaetivityof酬 啷 tinbothinexWatmalandinlrafmaifm哪 intremeda瞻 伪| 咖 ．
I1．e~mm oreaetivity0fialrafomlfilm sincreased 1adyaf恼 印sp即si佃 andreadiedthehi levelat3d| m~ter
tail-~npension． tmm~ ty0fextmfusalrtlmm in唧 sedafter3adys 硼sp删 m andreadiedthe柚 tlevel
after7adys tail-suspension，whichwasl~verthan—th—atininlrafusalfibersafter3daystail-suspe=tm ．C ndl嚣 n
resultssu88estthatsoleusatrophy0fintrafusalfmerscansedbytan-s=pees~ isearl~ andmille鲫 骶 thanthat
inexWafesalfibers．
KEYWORDS：ubiqnitin；stmaated-~ ty；ilno~leal3rophy；miisdespindle；tail．锄 恤
CLCr_ r：R852．22 Doctrnentcode：A ArticleID：1671．8267(2003)01．0025．04
Musclesize isdetermined by thebalancebe- ATP-ubiqui
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