原创力文档a patient with minimal change disease and acute focal tubulointerstitial nephritis due to traditional medicine a case report and small literature review：一个微小病变和急性局灶性肾小管间质性肾炎由于传统医学病例报告及文献回顾病人的小.pdf
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a patient with minimal change disease and acute focal tubulointerstitial nephritis due to traditional medicine a case report and small literature review：一个微小病变和急性局灶性肾小管间质性肾炎由于传统医学病例报告及文献回顾病人的小
CASE REPORT
A PATIENT WITH MINIMAL CHANGE DISEASE AND ACUTE FOCAL
TUBULOINTERSTITIAL NEPHRITIS DUE TO TRADITIONAL MEDICINE: A CASE
REPORT AND SMALL LITERATURE REVIEW
Keun-Hyeun Lee, KMD,1,2 Han-Sol Jeong, PhD, KMD,3,♯ and Harin Rhee, MD4,5
Gongjin-dan (GJD) is a traditional formula that is widely used the possible pathogenesis of GJD-induced minimal change
in Korea and China, and it has been used from 1345 AD in disease and review the adverse effects of GJD’s ingredients and
China to improve the circulation between the kidneys and the traditional Chinese medicines that can induce proteinuria. We
heart and to prevent all diseases. However, its adverse effects report a new adverse effect of GJD, which might induce
have not yet been reported. We present a patient with increased IL-13 production and an allergic response, leading to
minimal change disease and focal tubulointerstitial nephritis minimal change disease and focal tubulointerstitial nephritis.
associated with GJD. A 72-year-old man visited the clinic for
generalized edema 20 days after starting GJD. His serum Key words: Acute interstitial nephritis, minimal change
albumin level was low and nephrotic-range proteinuria was nephrotic syndrome, adverse effect, toxin, TCM, nephrotoxin
detected. A kidney biopsy showed minimal change disease and
acute tubulointerstitial nephritis. After stopping GJD, a (Explore 2014; 10:319-323 2014 Elsevier Inc. All rights
spontaneous complete remission was achieved. We discuss reserved.)
INTRODUCTION Chinese medicines (TCM) terminology and prevented all
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