儿童急性早幼粒胞白血病临床研究.pdf

儿童急性早幼粒细胞白血辅临床研究 儿童急性早幼粒细胞白血病临床研究 临床特征、早期死亡率、完全缓解率无关，对远期疗效亦无统计学意义上的影响。 第一次巩固治疗采用单用蒽环类药物治疗较联合化疗组患儿骨髓抑制的时间明 显缩短。6例临床复发，2例分子生物学复发，复发部位均为骨髓。5年累计复 结论儿童APL的预后良好，维甲酸诱导、维持治疗联合定期强化治疗远期疗效 较好。降低早期死亡率及复发率是进一步改善预后的重要途径。 【关键词】．自血病早幼粒细胞急性儿童 3 儿童急性早幼粒细胞白血病临床研究 Aclinicalforchildhoodwithacute leukemia study promyelocytic Toevaluatetheclinical and [Abstract]0bjective outcomeofacute Since promyelocyticleukaemia(APL)in than18 APLwere November included． 1991，102 years)proven children(younger Fourteenfailedtobetreatedduetotheeconomicalreason．Datafromothers patiems were 10．0 software．Result analyzed耐出SPSSsystem Sixty-one 41 in was wereincludedthis median gifts age缸diagnosis13(3 00．2％1 study．The -1 oldChildhoodAPLwerecharacterized fever． 8)years by TheWBCcountat w鹤morethan10×10讥，iIl32 presentation immunophenotypeofAPLwas thelow CD64、CD38、CDll7、H1T4(CD99R)andexpress studiesdemonstratedcharacteristictranslocationinabout Cytogenetic the 15；17 643％ofthe56 Ct caseswas93．8％ofthe64 patientsanalyzed，PML／RARpositive