“活血熄风法”疗帕金森病的理论与实验研究.pdfVIP

提 要 目的：研究“活血熄风法”对帕金森病 PD 的治疗作用及其机理。方法：① 实验研究；建立PD大鼠模型，用“活血熄风法” 血府逐瘀汤 干预，观察其全血 黏度、瘀血症状、血浆纤维蛋白原、血小板聚集率、中脑多巴胺含量、行为学体征的 变化。②文献研究：分析中医学和现代医学文献，探讨“活血熄风法”治疗PD的可 能机理。结果：①实验研究：血府逐瘀汤明显降低PD模型大鼠全血黏度，缓解其瘀 血症状，并可降低其中脑多巴胺含量，改善其行为学体征的异常。②文献研究：瘀血 是导致PD风气内动的重要病理基础，“活血熄风法”可治疗PD，对PD的氧化应激、 细胞凋亡、免疫异常等病理变化具有对抗作用。结论：“活血熄风法” 血府逐瘀汤 对PD模型大鼠具有一定治疗作用。“活血熄风法”通脉养筋治疗PD，可能与调节“多 巴胺一乙酰胆碱”平衡状态、抗氧化应激、抗细胞凋亡、免疫调节等机制有关。 关键词活血熄风法；帕金森病；理论探讨；实验研究 and researchon Parkinson’s Theoretical experimentaltreating withthe method blood disease therapeuticof。promoting to the eirculationcalmwind— ofTCM Specialty：BasicTheory Author：Liu Gang Tutor：Prof．LiuZhao--ehun Abstract the andmechanism effect of Parkinsons Objeetive：Tostudytherapeutic treating diseasewiththe method bloodcirculationto therapeuticof‘promoting calmthewind’． with research：ratmodelParkinson’sdiseasewasmade，the Methods：①Experimental to method bloodcirculationcalmthe fuzhu therapeuticof‘promoting wind’ xueyutang usedtotreat was therat ofblood model，the change viscosity,plasma ofblood contentin rate，symptoms midbrain，ethologysigns agglutination stasis，dopamine weremeasuredand research：TraditionalChineseMedicineand observed．②Document modemmedicinedocumentswere mechanismof the analyzed，thepossible using methodof bloodcirculationtocalmthewind the therapeutic promoting treating Parkinson’sdiseasewas research：theblood discussed．Results：OExperimentalviscosity bloodstasis were contentofthe inthe reduced，the remiss。the symptoms dopamine midbrain ofthe were afterthexnefuzhu reduced，the signs abnormalityethology changed wasusetotherat yu model．Butthe tang plasmafibrinogen,plateletagglutination ratedidn’t research：bloodstasiswasan changeobviously．②Document important base that wind．Parkinsonsdiseasecanbe pathological easingendogenous canbe treated，oxidative ofParkinson’sdisease stress，apoptosis，dys／mmunity antagonized the bloodcireulationtocalmthewind”． byusing therapeuticmethod“promoting method bloodcirculationtocal／nthe Conclusions：11忙t