脂蛋白脂酶基因HindⅢ酶切多态性与2型糖尿病的关联研究.pdfVIP

HEREDITAS (Beijing) 2007 8 , 29(8): 929933 ISSN 0253-9772 DOI: 10.1360/yc-007-0929 Hind 2 1, 1, 2 , 1 1. , 430079; 2. , 443100 : (lipoprotein lipase, LPL) Hin d 2 (type 2 diabetes mellitus, T2DM) , - - , PCR-RFLP , 264 T2DM 102 LPL Hind , T2DM H+ H+H+ (H+: 76.9% 69.1%, P0.05; H+H+: 59.8% 52%, P0.05) , T2DM H+ H+H+(H+: 81.5% 67.8%, P0.05; H+H+: 68.5% 50.7%, P0.05), (P0.05) Logistic T2DM LPL , H+H+ T2DM H+H- H-H- 1.995 (95% CI: 1.036 3.840, P0.05) LPL Hind T2DM , H+ T2DM : 2 Association of Hind RFLP in lipoprotein lipase gene with type 2 diabetes 1 1 2 1 DU Ji-Kun , HUANG Qing-Yang , LI Shou-Hua , XIONG Guo-Mei 1. College of Life Sciences, Central China Normal University, Wuhan 430079, China; 2. Yiling Hospital of Yichang, Yichang 443100, China Abstract: We examined the association of a Hind RFLP (restriction fragment length polymorphism) in the lipoprotein lipase (LPL) gene with type 2 diabetes (T2DM) in Chinese Han population in Hubei Province. Genotypes were determined by PCR-RFLP in 102 controls and 264 T2DM patients using sib-pair and unrelated case-control designs. The frequencies of the H+ allele and H+H+ genotype for patients were significantly higher than those for controls (H+: 76.9% vs 69.1%, P0.05; H+H+: 59.8% vs 52%, P0.05). When all subjects were grouped as designed, the H+ allele and H+H+ genotype for sib patients were significantly higher than those for sib controls (H+: 81.5% vs 67.8%, P0.05; H+H+: 68.5% vs 50.7%, P0.05), while there were no significant differences in controls and random pat