衰老或肿瘤_ 端粒酶和p53的相互作用.pdfVIP

HEREDITAS (Beijing) 2009 5 , 31(5): 451―456 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2009.00451 衰老或肿瘤: 端粒酶和p53 的相互作用 张秀峰, 唐文如, 罗瑛 , 650224 端粒酶和p53 两者在肿瘤和衰老的发生发展过程中都起着关键的作用。在人类大多数的肿瘤中都发现了 这一现象: p53 基因发生突变和端粒酶的重新激活。端粒酶和p53 基因的治疗逐渐成为肿瘤治疗的重要手段之 −/ − +/+ −/ − −/ − 一。文章论述了端粒酶或p53 基因敲除的不同组合的小鼠模型(mTR p53 ; mTR P53 ) 的衰老与肿瘤表型, 对端粒功能异常可抑制或促进肿瘤发生的辩证作用作一综述, 以期理解p53 与端粒酶在衰老与肿瘤发生中的辩 证相互作用, 寻求一种治疗肿瘤的新思路。 端粒酶; p53 ; 肿瘤; 衰老 Aging or tumor: the crosstalk between telomerase and p53 ZHANG Xiu-Feng, TANG Wen-Ru, LUO Ying Lab of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China Abstract: Telomerase and p53 play critical roles in tumorigenesis and senescence. The mutation of p53 gene and the reac- tivation of telomerase have been found in most of the human tumors. Aiming telomerase and p53 genes have become im- portant strategies in tumor therapy. We reviewed the aging and tumor phenotype in different status of telomerase and p53 −/ − +/+ −/ − −/ − (mTR p53 ; mTR P53 ), which indicated that telomere dysfunction could initiate or suppress the tumorigenesis de- pending on the status of p53 . This helps further understanding of the crosstalk between p53 and telomerase in aging and tumorigenesis, and provides a new idea for treating tumor. Keywords: telomerase; p53 ; tumorigenesis; aging , , , , , , , DNA , BFB(Breakage-fus