癌性周围神经病.doc

Carcinomatous peripheral neuropathy 1. BMJ Case Rep. 2015 Nov 30;2015. pii: bcr2015213123. doi: 10.1136/bcr-2015-213123. POEMS syndrome: complex factors contributing to a delayed diagnosis. Robey RC(1), Campus C(2), Ringuette B(3), Shumate M(2). Author information: (1)School of Medicine, Kings College London, London, UK. (2)School of Medicine, Emory University, Atlanta, Georgia, USA. (3)Atlanta Veteran Administration Medical Center, Atlanta, USA. POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes) syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell disorder. The chronically evolving nature of this syndrome and diverse clinical manifestations make it a challenging diagnosis, especially in the early stages of the disease. We present a case that illustrates well how these confounding factors can delay recognition of the disorder. We describe the presentation of some of the classical symptoms, and discuss how investigations can be optimised in order to fit together the clinical picture. Recent advances in the understanding of nerve conduction studies and electromyography in POEMS may help improve the early identification of this disease. This is of great importance, as early recognition and the initiation of appropriate treatment can reduce morbidity and mortality in POEMS. 2015 BMJ Publishing Group Ltd. PMID: [PubMed - in process] 2. Ann Clin Lab Sci. 2015 Nov;45(6):702-6. POEMS Syndrome with IgG-λ/IgA-κ Biclonal Gammopathy and Abnormal Serum Free Light Chain Ratio: a Case Report. Ham JY(1), Suh JS(2), Lee WK(2), Song KE(3). Author information: (1)Department of Laboratory Medicine, Kyungpook National University Hospital, Daegu, Korea. (2)Department of Laboratory Medicine, Kyungpook National University Hospital, Daegu, Korea Department of Clinical Pathology, Kyungpook National University School of Medicine, Daegu, Korea. (3)Department of Clinical Pathology, Kyungpook National University School