磁靶向纳米载药体的制备.pdfVIP

磁靶向纳米载药体的制备 袁远，姜炜 （国家特种超细粉体工程技术研究中心，江苏南京，210094 ） 摘 要：利用磁性材料的靶向性以及纳米材料粒径小，容易被人体吸收地特点，用一种简单的方法制 备一种安全，无毒副作用的靶向载药体，与抗癌药物结合后，可准确、安全、有效地用于治疗癌症。 制备过程如下：先用共沉淀法制备出 Fe O 磁性粒子，再用声化学乳液法合成果胶包覆磁性纳米球。 3 4 运用 TEM、磁性能、红外光谱和热重分析等对 Fe O 磁性粒子进行表征。结果表明，制备得到的 Fe O 3 4 3 4 磁性粒子粒径为 10nm 左右，粒径分布较好，分散性良好，纳米球没有明显的磁滞现象，磁含量较 高，磁响应性好。当果胶为 0.4g，磁流体 1mL，氯化钙 0.4g，十二烷基苯磺酸钠 0.15g，超声时间 30min 时，包覆效果达到最佳，由 TEM 可以看出，形成的磁性纳米球成球性较好，粒径大概为 100-200nm，粒径分布较好，分散性好。 关键词：Fe O ；磁靶向；药物载体； 3 4 The Preparation of magnetic targeted drug loading body Yuan Yuan ，Wei Jiang （National Special Superfine Powder Engineering Research Center, Nanjing, jiangsu,210094） Abstract: Take advantage of the properties such as the magnetic target of magnetic materials, small dimension effect of nano-material and easily to be absorbed by the body ,we prepare a safe, non-toxic side effects targeted drug loading body using a simple method. After combination with anticancer drugs, it can be used in the treatment of cancer. Preparation processes are as follows: First, prepare Fe3O4 magnetic particles by co-precipitation method, then prepare the magnetic nanoparticles coated by pectin.Fe3O4 particles were characterized using TEM, magnetic properties, FT-IR and TG.The results show that, the prepared Fe3O4 magnetic particles are about 10nm, have good dispersion, the nanospheres have no obvious hysteresis, have higher content magnetic and good magnetic responsiveness. Keywords: Fe3O4; magnetic targeting; drug carrier; 1 绪论 随着人类文明和科技的进步，人类