基于天然产物的药物研发对创新中药的研究的启示—ttd收录天然药物分析.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 12, 47 ( 11): 1423 1427 ·1423 · 于天然产物的药物研发对创新中药研究的启示 TTD 收录天然药物分析 * 陈修平, 陆金健, 郭佳杰, 鲍娇琳, 徐文珊, 丁 倩, 王一涛 ( 中药质量研究国家重点实验室, 中华医药研究院, 澳门大学, 澳门 999078) 摘要: 天然产物一直是新 研发的重要源泉, 创新中药研发是中 现代化、国际化的关键环节。但由于中 系统的复杂性, 目前创新中 研发尚存在诸多困难和困惑。基于靶点的 物研发是药物发现的主要模式和手段。 TTD (therapeutic target database) 是新加坡国立大学开发的治疗靶点数据库, 除收录大量的药物靶点信息外, 还 包含了大量天然产物的相关信息。本文简单介绍了TTD, 通过分析TTD 中收录的天然来源的药物/化合物, 探讨 了对创新中 研发的启示。 关键词: 靶点; 治疗靶点数据库; 天然产物; 中 ; 新药研发 中图分类号: R93 1 文献标识码: A 文章编号: 05 13-4870 (20 12) 11-1423-05 Inspirations from natural products based drug research and development for Chinese medicine research Analysis of natural products recoded in TTD * CHEN Xiu-ping , LU Jin-j ian, GUO Jia-ji e, BAO Jiao-lin, XU Wen-shan, DING Qian, WANG Yi-tao (State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China) Abstract: Natural product is an important source of new drug research and development (RD). Traditional Chinese medicine (TCM) innovation is the key step for its modernization and internationalization . However, due to the complexity of TCM, there are many difficulties and confusions in this process. Target-based drug discovery is the mainstream model and method of RD. TTD, short for therapeutic target database, is developed by National University of Singapore. Besides a large amount of informatio