肠源性内毒素血症早期肝脏和肺损伤关系研析.pdfVIP

1 目 录 1. 论文：„„„„„„„„„„„„„„„„„„„„„ 2 中英缩略词对照表„„„„„„„„„„„„„„„„ 3 中文摘要„„„„„„„„„„„„„„„„„„„„ 4 英文摘要„„„„„„„„„„„„„„„„„„„„ 6 前言„„„„„„„„„„„„„„„„„„„„„„ 9 材料与方法„„„„„„„„„„„„„„„„„„„10 结果„„„„„„„„„„„„„„„„„„„„„„19 讨论„„„„„„„„„„„„„„„„„„„„„„30 结论„„„„„„„„„„„„„„„„„„„„„„33 参考文献„„„„„„„„„„„„„„„„„„„„34 2. 综述：„„„„„„„„„„„„„„„„„„„„„37 3. 致谢：„„„„„„„„„„„„„„„„„„„„„46 4. 作者简介：„„„„„„„„„„„„„„„„„„„47 大黄附子汤对失血性休克复苏后致炎通路肠-肝-肺轴干预作用的机制研究 （项目批准号 2 中英文缩略词表 缩略词 英文全称 中文全称 LPS lipopolysaccharide 内毒素 IETM intestinal endotoxemia 肠源性内毒素血症 TNF-α tumor necrosis factor-α 肿瘤坏死因子- α SIRS systemic inflammation response syndrome 全身性炎症反应综合征 ARDS acute respiratory distress syndrome 急性呼吸窘迫综合征 MODS multiple organ dysfunction syndrome 多器官功能障碍综合征 CC16 clara cell protein 克拉拉细胞蛋白 ALI acute lung injury 急性肺损伤 KC kupffer cells 枯否氏细胞 compensatory anti-inflammatory response 代偿性抗炎反应综合征 CARS syndrome PMN polymorphonuclear leukocyte 多形核白细胞 BALF bronchoalveolar lavage fluid 肺泡灌洗液 AM alveolar macrophages 肺泡巨噬细胞 LBP lipopolysaccharide bingding protein 内毒素结合蛋白 TLR4 toll-like receptor 4 Toll 样受体4 3 肠源性内毒素血症早期肝脏与肺损伤关系的研究 中文摘要 目的：通过研究经门、腔静脉途径注入内毒素后所致急性肺损伤的差异，以揭 示肠源性内毒素血症早期肝脏与肺损伤的关系。 方法：72 只健康清洁级SD 大鼠