分子生物学第四章2详解.ppt

Why are proteins modified? Regulation of activity turn activity on turn activity off generate a different function Protein-protein interaction modification site may be a binding interface Subcellular localization modification site may be a targeting signal modification may be a membrane anchor Degradation identify the protein for degradation …… Functions of glycosylation Proper folding 正确折叠 Stabilise proteins against proteolysis 防止降解 Form ECM (extracellular matrix) 胞外基质 Modulation of immune response 免疫反应 Selectins bind to oligosaccharides, cell-cell interactions Anchor proteins on