HIV和HBV协同作用的数学建模及HBV疫苗接种的潜在影响分析.pdf

Abstract 硕士论文 Abstract Hepatitis B virus(HBV)and human immunodeficiency virus(HIV)are among the top 10 leading causes of infectious disease deaths worldwide．Since HIV and HBV have similar modes of transmission being transmitted by blood transfusion and by percutaneous／permucosal routes，coinfection with both virus is common．Because the biological and epidemiologica]evidences suggest that HIV and HBV have synergi。stic effects，in order to better understand the transmission dynamics of HIV and HBV，it is interesting and necessary to investigate the epidemiological synergy between HIV and HBV at the population level and to evaluate the potential impact of HBV vaccination strategy 0n HIV transmission． Mathematical models are wonderful tools for gaining insights into the transmis— sion and control of infectious diseases．Based on the understanding of the synergy between HIV and HBV．a deterministic compartmental epidemic model is formulated to describe the transmission dynamics and interaction between HIV and HBV．Then the basic reproduction numbers for HIV and HBV are derived by using the approach of next generation matrices，respectively．In order to get insights into the dynamics of the models for HIV only and HBV only,the local and global behavior of the HIV- only subsystem and HBV-only subsystem are respectively classified by using the basic reproduction numbers．Subsequently,using the same approach of next generation ma,- trices，the invasion reproduction numbers for HIV and HBV infection are also defined， respectively，and then the basic and invasion reproduction numbers are used to classify the stability of the boundary equilibria of the full system and also provide information about the coexistence of both infectious diseases． The theoretical results obtained in this paper are not only tested but also extended by numerical simulations．A set of reasonable parameter values for the full system are further chosen to numerically evaluate the potential impact of HBV and its vacc