吉林地区仔猪水肿病流行病学调查和灭活疫苗的制备.pdfVIP

Abstract Since the first report of edema disease(ED)of piglets(Shanks，1 938)，it had been assured that this disease now had taken place in nearly all porcine breeding countries around the world．This disease frequently happens to well—developed piglets in one or two weeks after weaning．Usually,it suddenly breaks out and has an incidence as high as ten to thirty percents,and the mortality is as high as ninety percents．Accordingto the primary statistic，about 5,000 piglets would be subject to this disease and about 1,300 piglets Would die of this disease in Jilin region every year．Therefore，in order to decrease the economic loss and effectively control the disease，it is necessary to investigate the epidemiology of piglet edema disease．And this work will benefit the control ofpiglet edema disease． In this paper,we investigated the incidence of the disease and the mortality of piglet edema in several towns ofJilin in 2006．The results demonstrated that piglet edema t0Iok place sporadically in Jilin region． The incidence of the disease in Jilin country Was about 0．29—1．36 percents；the mortality Was about 0．08-0．35 percents；the mortality in infected piglets Was about 16．0-35．0 percents．This disease mainly happened to post-weaning piglets，occasionally to growing pig and often happened in April、May、 September and October every year．8 strains of Escherichia coil had been isolated from sick or dead piglets．They were identified as Escherichia coli by its morphology,culture and biochemical characteristics．The pathogenicity trial in mousos showed that they were all pathogenic bacteria．8 strains were classified into 4 serotypes：Os，0139，O=41，and 02．Among them，Os，0139 and 0141 were the predominant sterotypes．Polyvalent inactivated vaccine Was prepared with predominant-serotype E．coli． Piglets were inoculated with different dose of inactivated vaccine．The results showed that when susceptible piglets were inoculated with 6x 1 08 CFU per piglet,these piglets would have stronger immunity．T