浙江大学医学免疫学部分英文答案.docVIP

Questions: Please describe the concepts of TD-Ag and TI-Ag respectively and compare the differences between TD-Ag and TI-Ag. Thymus -dependent antigens are those that do not directly stimulate the production of antibody without the help of T cells. B cell epitope ＋ T cell epitope Humoral immunity and cellular immunity Antibody :five types Immune memory Proteins are thymus -dependent antigens. Thymus -independent antigens are antigens which can directly stimulate the B cells to produce antibody without the requirement for T cell help In general. only B cell epitope Humoral immunity Antibody: IgM No Immune memory polysaccharides are TI- antigens. Please describe the general properties of cytokine. General properties of CKs Small proteins MW: approx. 15-30 KD Extremely potent, acting at pM or fM The production is transient and tightly regulated Autocrine, paracrine or endocrine Non-specific and non-MHC restricted What are the rules of antibody production in vivo? What are the general features of antibody responses in vivo? B cell and HMI ppt P65.表格作参考，表格下的文字为主。 Primary response Secondary response Lag after immunization Usually 5-10 days Usually 1-3 days Peak response Smaller Larger Antibody isotype Usually IgM IgG Relative increase in IgG and, under certain situations, in IgA or IgE heavy chain class switching Antibody affinity Lower average affinity, more variable Higher average affinity affinity maturation Primary immune response - longer latent phase; - smaller peak response lower Ab titer ; - remaining in the serum at detectable levels for much shorter periods; - lower average affinity; - usually IgM; Secondary immune response The immune response followed by secondary antigenic challenge - shorter latent phase; - bigger peak response higher Ab titer ; - remaining in the serum at detectable levels for much longer periods; - higher average affinity; - usually IgG. Please describe the general process of CD4+ T cell mediated