亚胺培南西司他丁治疗婴幼儿重症细菌感染效果及不良反应分析.docVIP

亚胺培南西司他丁治疗婴幼儿重症细菌感染效果及不良反应分析 　　[摘要] 目的 研究分析亚胺培南西司他丁治疗婴幼儿重症细菌感染的临床治疗效果以及不良反应。 方法 随机选取2014年8月―2015年7月该院收治的80例婴幼儿重症细菌感染患者，随机分成两组。对照组40例，采用美罗培南治疗；观察组40例，给予亚胺培南西司他丁治疗。统计比较两组患儿的治疗总有效率、细菌清除率以及发生不良反应的概率。 结果 观察组患儿治疗总有效率较对照组更高，差异具有统计学意义（P0.05）；观察组患儿清除感染细菌的机率高于对照组，差异具有统计学意义（P0.05）；观察组患者发生不良反应的概率低于对照组，差异具有统计学意义（P0.05）。结论 亚胺培南西司他丁治疗婴幼儿重症细菌感染能够有效清除病原细菌，降低治疗不良反应，临床疗效十分显著。 　　[Abstract] Objective To research and analyze the clinical treatment effect and adverse reaction of lmipenem-cilastatin sodium hydrate in treatment of severe bacterial infection in infants. Methods 80 cases of infants with severe bacterial infection treated in our hospital from August 2014 to July 2015 were selected and randomly divided into two groups with 40 cases in each， the control group were treated with meropenem， the observation group were treated with lmipenem-cilastatin sodium hydrate， the total treatment effective rate， bacterial eradication rate and incidence of adverse reactions of the two groups were counted and compared. Results The total treatment effective rate in the observation group was higher than that in the control group， and the difference was statistically significant （P0.05）， the bacterial eradication rate in the observation group was higher than that in the control group， and the difference was statistically significant（P0.05）， the incidence of adverse reactions in the observation group was lower than that in the control group， and the difference was statistically significant（P0.05）. Conclusion Imipenem-cilastatin sodium hydrate in treatment of severe bacterial infection in infants can effectively clear pathogenic bacteria and reduce the adverse reactions of treatment， and the clinical curative effect is very significant. 　　[Key words] Imipenem-cilastatin sodium hydrate； Infant； Severe bacterial infection 　　婴幼儿是婴儿和幼儿的统称，一般是指0～3岁的小龄孩子[1]。婴儿与幼儿之间有莫大的联系，婴幼儿身体组织器官功能发育尚未成熟，器官功能与生活适应能力都比较差，并且免疫能力也未健全，抵抗力较差，极易发生细菌感染在临床中如果护理不周会有比较高的死亡率[2]。随机选取2014年8月―2015年7月该院收治的80例婴幼儿重症细菌感染患者，该研究就亚胺培南