奥卡西平联合鼠神经生长因子治疗带状疱疹神经痛临床观察.docVIP

奥卡西平联合鼠神经生长因子治疗带状疱疹神经痛临床观察 　　【摘要】 目的 探讨奥卡西平联合鼠神经生长因子（mNGF）治疗带状疱疹神经痛的临床效果。方法 46例带状疱疹神经痛患者， 随机分为观察组与对照组， 各23例。两组患者均给予阿昔洛韦和甲钴胺治疗；观察组在此基础上加用鼠神经生长因子肌内注射， 奥卡西平口服。观察两组治疗前及治疗后1、2、4周时神经痛视觉模拟评分法（VAS）评分改善程度及临床疗效。结果 用药后观察组VAS评分、临床疗效均显著优于对照组， 差异有统计学意义（P0.05）。两组均无严重不良反应发生。结论 奥卡西平联合鼠神经生长因子治疗带状疱疹神经痛效果显著， 值得临床推广。 　　【关键词】 奥卡西平；鼠神经生长因子；带状疱疹；神经痛 　　DOI：10.14163/j.cnki.11-5547/r.2015.29.006 　　Clinical observation of oxcarbazepine combined with mouse nerve growth factor in the treatment of herpes zoster neuralgia YU Yin. Department of Neurology， Yixing City People’s Hospital， Yixing 214200， China 　　【Abstract】 Objective To investigate clinical effect of oxcarbazepine combined with mouse nerve growth factor （mNGF） in the treatment of herpes zoster neuralgia. Methods A total of 46 patients with herpes zoster neuralgia were randomly divided into observation group and control group， with 23 cases in each group. Both groups received acyclovir and mecobalamine for treatment. The observation group received additional mouse nerve growth factor by intramuscular injection and oxcarbazepine by oral administration. Visual analogue scale （VAS） score improvement and clinical effect were compared between the two groups before and after 1， 2， 4 weeks of treatment. Results After medication， the observation group had much better improvement in VAS score and clinical effect than the control group， and their difference had statistical significance （P0.05）. Both groups had no severe adverse reactions. Conclusion Combination of oxcarbazepine and mouse nerve growth factor provides precise effect in treating herpes zoster neuralgia， and this method is worthy of clinical promotion. 　　【Key words】 Oxcarbazepine； Mouse nerve growth factor； Herpes zoster； Neuralgia 　　带状疱疹是水痘-带状疱疹病毒所导致的一种病毒性皮肤病， 其主要表现为沿一侧周围神经呈带状分布的成簇水疱， 常伴有明显的神经痛， 其疼痛是由病毒侵犯皮肤的感觉神经末梢而致神经发炎、坏死所致， 属神经病理性疼痛， 甚至部分患者疱疹愈合后仍遗留顽固性神经痛， 从而影响生活质量。早期积极治疗可较好地控制急性期症状， 并有效预防带状疱疹后遗神经痛的发生。作者采用奥卡西平联合鼠神经生长因子联合治疗带状疱疹神经痛， 取得较好疗效， 现报告如下。 　　1 资料与方法 　　1. 1 一般资料 选择