奥曲肽对术后早期炎性肠梗阻患者血清内毒素和超敏C反应蛋白水平的影响.docVIP

奥曲肽对术后早期炎性肠梗阻患者血清内毒素和超敏C反应蛋白水平的影响 　　[摘要] 目的 探讨奥曲肽用于治疗腹部手术后早期炎性肠梗阻的疗效及对患者血清内毒素（LPS）和超敏C反应蛋白（hs-CRP）水平的影响。 方法 选取腹部手术后早期炎性肠梗阻患者64例，随机分为观察组（n=32）和对照组（n=32）。两组均予以常规治疗，包括禁食、持续胃肠减压、抗感染、静脉营养、维持水电解质和酸碱平衡等。观察组加用奥曲肽针0.1 mg皮下注射，q8h。对照组除不使用奥曲肽针余治疗同观察组。观察两组患者治疗前和治疗6 d后血清LPS和hs-CRP水平的变化，并比较其疗效及不良反应。 结果 治疗6 d后，两组患者血清LPS和hs-CRP水平较前均有不同程度下降（P0.05）。 结论 奥曲肽用于治疗腹部手术后早期炎性肠梗阻的疗效较显著，安全性亦较好，这与其能明显降低患者血清LPS和hs-CRP水平的作用机制密切相关。 　　[关键词] 腹部手术；早期炎性肠梗阻；奥曲肽；内毒素；超敏C反应蛋白 　　[中图分类号] R656.7 [文献标识码] B [文章编号] 1673-9701（2015）12-0084-03 　　Influence of octreotide on serum LPS and high sensitive C-reactive protein （hs-CRP） levels for patients with early postoperative inflammatory intestinal obstruction 　　WEN Jiuhui1 LUO Shiyun1 XIA Zhongping1 HUANG Hongbin1 CHEN Jianfeng2 　　1.General Surgery Department，Taizhou Cancer Hospital in Zhejiang Province，Taizhou 317502，China；2.Surgery Department， Affiliated Hospital of Hangzhou Normal University， Hangzhou 310015，China 　　[Abstract] Objective To discuss curative effect of Octreotide on early inflammatory intestinal obstruction after abdominal operation and its influence on serum LPS and High sensitive C-reactive protein （hs-CRP） levels. Methods All 64 cases of patients with early inflammatory intestinal obstruction after abdominal operation were selected and divided into observation group （n=32） and control group （n=32） at random. The patients in two groups were given routine medical treatment， such like fasting， instant gastrointestinal decompression， anti-infection， intravenous nutrition， maintenance of water-electrolyte and acid-base balance and etc. The patients in observation group were additionally given 0.1mg Octreotide by hypodermic injection， q8h， while the patients in control group were given the same medical treatment as that in observation group except for Octreotide. The changes of serum LPS and hs-CRP levels of patients in two groups before and 6 days after the medical treatment， and the curative effect and untoward effect was compared as well.