孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘（CVA）的疗效.docVIP

孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘（CVA）的疗效 　　[摘要] 目的 探讨小儿CVA采取布地奈德联合孟鲁司特钠治疗的疗效。方法 选取68例于近1年期间该院接收的CVA患儿，将其平分为对照组和研究组，将雾化吸入布地奈德给予对照组作为治疗手段，布地奈德联合孟鲁司特钠给予研究组作为治疗手段，观察两组疗效。 结果 对照组疗效明显差于研究组（P0.05），两组药不良反应均较轻微，同时研究组肺功能指标在治疗后有明显改善，且改善明显优于对照组（P0.05）。结论 CVA采取布地奈德联合孟鲁司特纳治疗，效果显著，值得推广。 　　[关键词] CVA；布地奈德；疗效；孟鲁司特钠 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-0742（2015）06（a）-0110-02 　　Curative Effect of Montelukast Combined with Budesonide on Children Cough Variant Asthma （CVA） 　　YANG Xia， ZHANG Yan-qiu， XI Yan-hua， YU Rui-miao， ZHANG Fan 　　Department of Respiratory Medicine， the Harbin Children’s Hospital， Harbin，Heilongjiang Province， 150000 China 　　[Abstract] Objective To probe into the curative effect of Montelukast combined with budesonide on children cough variant asthma （CVA）. Methods 68 CVA children who received treatment in our hospital in the past year were selected and divided into the control group and the research group. The control group was treated with budesonide through aerosol inhalation and the research group was treated with Montelukast combined with budesonide. The curative effects of the two groups were observed. Results The curative effect of the control group was obviously poorer than that of the research group （P0.05）. The side effects of both groups were relatively slight. Meanwhile， the lung function index of the research group was improved significantly after treatment， which was also obviously better than that of the control group （P0.05）. Conclusion The curative effect of Montelukast combined with budesonide on children variant asthma （CVA） is remarkable， so it is worth promotion. 　　[Key words] CVA； Budesonide； Curative effect； Montelukast 　　咳嗽变异性哮喘（CVA）是临床儿科常见疾病，慢性咳嗽为该病的主要临床表现。临床上既往常采取糖皮质激素治疗，但部分患儿咳嗽症状仍不能得到控制。近年来，孟鲁司特钠应用于临床，取得较好成效[1]。该研究探讨小儿CVA采取布地奈德联合孟鲁司特钠治疗的疗效，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　整群选取68例于近1年期间该院接收的CVA患儿，入选者均符合小儿咳嗽变异性诊断标准，患儿咳嗽时间均超过4周，主要以干咳为主，常在清晨或夜间发作或加重，临床无感染征象，对抗哮喘药物有效，长时间使用抗菌药物无效。排除其他原因引起的慢性哮喘，患儿于治疗前均未使用糖皮质激素β2-受体激动剂。研究组中，女15例，男19例，年龄2～10岁