痛泻宁颗粒联合金双歧治疗腹泻型肠易激综合征随机对照研究.docVIP

痛泻宁颗粒联合金双歧治疗腹泻型肠易激综合征随机对照研究 　　【摘要】 目的：观察痛泻宁颗粒与双歧杆菌乳杆菌三联活菌片（金双歧）联用治疗腹泻型肠易激综合征的疗效。方法：采用随机、平行对照研究方法，将75例符合入选标准的IBS-D患者分为A组（痛泻宁加金双歧试验组）及B组（单用痛泻宁组）、C组（单用金双歧组），每组各25例，对患者的腹痛、腹泻、总体症状进行评分，根据症状积分变化判断疗效。结果：治疗4周后三组患者治疗前后腹痛评分、腹泻评分和症状总评分比较差异均有统计学意义（P0.05）。疗效比较，A组与B组、A组与C组间腹痛、腹泻症状疗效及总体疗效比较差异均有统计学意义（P0.05）。结论：痛泻宁颗粒与金双歧联用治疗IBS-D可明显改善患者的核心症状，疗效更佳，无不良反应。 　　【关键词】 肠易激综合征； 痛泻宁颗粒； 双歧杆菌乳杆菌三联活菌片（金双歧）； 微生态制剂 　　Randomized and Controlled Study on Effects of Tongxiening Granule Combined with Golden Bifid for the Treatment of Diarrhea-predominant Irritable Bowel Syndrome/ZHAO Qing-wei，LYU Dao-xian.//Medical Innovation of China，2015，12（26）：068-071 　　【Abstract】 Objective：To observe the efficacy of combined Tongxiening granule and Golden Bifid for the treatment of patients with dominant-diarrhea irritable bowel syndrome.Method： Randomized and parallel-group study method was used， 75 IBS-D patients who met the inclusion criteria were divided into three groups： group A （combined Tongxiening granule and Golden bifid tablets study group）， group B （Tongxiening granule alone control group） and group C （Golden bifid tablets alone control group）， 25 cases in each group. The symptoms of abdominal pain， diarrhea and global symptom were scored. The efficacy was determined by the changes of symptom scores. Result：After treatment for 4 weeks，compared the abdominal pain scores， diarrhea symptoms scores and total symptoms scores of three groups before and after treatment， the differences were statistically significant（P0.05）.Compared the effect of three groups， group A had statistically significant difference with the other two groups（P0.05）.Conclusion：Adjunctive therapy of Tongxiening granule and Golden Bifid tablets for IBS-D obviously improve the core symptoms of patients， has a better curative effect and no adverse reaction. 　　【Key words】 Irritable bowel syndrome； Tongxiening granule； Live combined bifidobacterium and lactobacillus tablets（Golden Bifid）； Probiotics 　　First-author’s address：The Seco