左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床效果观察.docVIP

左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床效果观察 　　[摘要] 目的 探讨左炔诺孕酮宫内缓释系统对子宫腺肌病的临床治疗效果。 方法 以本院2010年1月～2012年12月收治的患有子宫腺肌病的78例患者为研究对象，均接受左炔诺孕酮宫内缓释系统治疗，观察其临床治疗效果。并对患者治疗前后的痛经程度、血雌二醇的变化以及月经量进行统计学分析比较。 结果 在放置左炔诺孕酮宫内缓释系统12个月后，疼痛消失者有54例，疼痛明显减轻有17例，无显著效果的5例，2例患者发生脱落。放置3、6、12个月后，月经量及疼痛程度与放置前比较，差异有统计学意义（P0.05）。 结论 左炔诺孕酮宫内缓释系统对子宫腺肌病的治疗具有明显的临床效果，同时卵巢的功能也没有受到显著的抑制作用，值得在临床上进一步推广应用。 　　[关键词] 左炔诺孕酮；宫内缓释系统；子宫腺肌病 　　[中图分类号] R711.7 [文献标识码] A [文章编号] 1674-4721（2014）09（a）-0038-03 　　Clinical effect observation of levonorgestrel releasing intrauterine system in the treatment of adenomyosis 　　ZHAO Hong 　　Department of Gynecology and Obstetrics，Jiangning Hospital Affiliated to Nanjing Medical University，Nanjing 211100，China 　　[Abstract] Objective To explore the clinical therapeutic effect of levonorgestrel releasing intrauterine system （LNG-IUS） in the treatment of adenomyosis. Methods Seventy-eight patients with adenomyosis admitted into our hospital from January 2010 to December 2012 were selected as research objects.The LNG-IUS was provided in all patients，and the clinical therapeutic effect was observed.The degree of dysmenorrhea，change of estradiol in blood，and menstrual blood volume before and after treatment were statistical analyzed and compared. Results Twelve months after placing LNG-IUS，summarization of therapeutic effect indicated that pain greatly alleviated in 17 cases and disappeared in 54 ones.Except that，there was no obvious effect in 5 cases and falling off in two patients.After 3，6，12 months，the menstrual blood volume and comprehensive score of pain had significant difference compared with before therapy （P0.05）. Conclusion LNG-IUS can obtain a remarkable clinical effect on treating adenomyosis and no significant inhibition on ovarian function occurred，which is worthy of further application and expansion in clinic. 　　[Key words] Levonorgestrel；Releasing intrauterine system；Adenomyosis 　　作为一种常见的疾病，子宫腺肌病的发病患者多见于育龄妇女，其主要的临床症状是患者经量增多，经期显著延长，同时出现进行性痛经且会呈现逐步加重的趋势发展，因此使患者的生活质量受到了严重的影响[1]。目前对于该