法舒地尔联合α―硫辛酸治疗2型糖尿病伴有勃起功能障碍患者的临床价值研究.docVIP

法舒地尔联合α―硫辛酸治疗2型糖尿病伴有勃起功能障碍患者的临床价值研究 　　【摘要】目的：探讨法舒地尔联合α-硫辛酸治疗2型糖尿病性勃起功能障碍（DMED）的临床价值。方法：连续选择2013年6月至2014年4月入我院内分泌科诊断为DMED患者共76例，平均年龄（467±72）岁，平均糖尿病病程（62±28）年，平均体质量指数（254±13）kg/m2。将其随机分入观察组40例和对照组36例，均予血糖控制治疗。观察组给予盐酸法舒地尔60mg、α-硫辛酸600mg分别加入250mL生理盐水中静滴，1次/d，疗程4周；对照组给予他达拉非5mg口服，1次/晚，4至6周为1个疗程。结果：研究无脱落病例，观察组治疗有效率明显高于对照组（950% vs.805%，P005）；治疗后观察组IIEF-5、EHGS评分及肱动脉FMD值均显著高于对照组（P005）；观察组不良反应发生率明显低于对照组（75% vs.139%，P005）。结论：法舒地尔联合α-硫辛酸可通过改善DMED患者血管内皮功能、勃起硬度达到治疗勃起障碍的目的，且少不良反应，安全性好。 　　【关键词】法舒地尔；α-硫辛酸；2型糖尿病；勃起功能障碍 　　【Abstract】Objectives： To study the effect of Fasudil combined with alpha lipoic acid in treatment of type 2 diabetes patients with impotence. Methods： A total of 76 patients diagnosed as type-2 diabetes with impotence from June 2013 to April 2014 in our hospital were selected. The mean age was （46.7±7.2） years； the mean diabetes course was （6.2±2.8） years and the mean body mass index was （25.4±1.3） kg/m2. The 76 patients were divided randomly into experiment group （n=40） and control group （n=36）， all receiving glucose control. The patients in experiment group received Fasudil 60mg and alpha lipoic acid 600mg+250mL NS once per day， for 4 weeks. The patients in control group received Tadalafil 5mg. Results： There was no loss of cases. the total efficacy rate in experiment group was significantly higher than that in control group （95.0% vs.80.5%， P0.05）； the IIEF-5， EHGS score and brachial artery FMD value in experiment group were significantly higher than these in control group （P0.05）； the incidence of complications in experiment group was significantly less than that of control group （7.5% vs.13.9%， P0.05）. Conclusion： Fasudil combined with alpha lipoic acid can greatly improve the treatment effect of patients with type 2 diabetes and impotence. 　　【Key words】Fasudil； Alpha lipoic acid； Type 2 diabetes； Impotence 　　【中图分类号】R698【文献标志码】A 　　勃起功能障碍（ED）是男性2型糖尿病常见并发症之一，美国国立卫生院报道糖尿病人约35%～75%合并ED症状。多数研究认为氧化应激引起的神经和血管病变在糖尿病性勃起功能障碍（DMED）发病中起到了重要作用[1]。目前糖尿病性ED尚缺少特效疗法，5型磷