磷脂酰丝氨酸重点.pptVIP

* 黄文龙 2016-03-05 Abstract: PS is also profoundly dysregulated in the tumor microenvironment and antagonizes the development of tumor immunity. In this review, we discuss the biology of PS with respect to its role as a global immunosuppressive signal and how PS is exploited to drive diverse pathological processes such as infection and cancer. Finally, we outline the rationale that agents targeting PS could have significant value in cancer and infectious disease therapeutics. 1.PS Asymmetry in Biological Membranes 2.Mechanisms of PS Externalization during cell Stress and Apoptosis Although the biochemical landscape for PS externalization is still incomplete, recent progress in this area has emerged following the cloning and characterization of two novel scramblases; transmembrane protein 16F (TMEM16F) and Xkr8 (ced-8), that externalize PS by distinct regulatory mechanisms. Calcium-dependent phospholipid scrambling by TMEM16F. Nature 2010; 468: 834–838. In contrast to TMEM16F, Xkr8 is not activated by Ca2+, but via a caspase 3/7-dependent pathway. 3.Not all Externalized PS is Functionally Equivalent 4.Immunological Consequences of PS;Homeostasis,Autoimmunity,and Cancer It has been known for almost two decades that apoptotic cells are potently immunosuppressive Three kinds of interrelated pathways that signal;(i) find me (ii) eat meand (iii) tolerate me. PS is one of the primary apoptotic cell ligands that provides eat-me signals to phagocytes. Engulfed apoptotic cells induce the secretion of the anti-inflammatory cytokine interleukin-10 (IL-10) and TGF-β and simultaneously decrease the secretion of the inflammatory cytokines TNF-α,IL-1β, and IL-12 5.Consequences of a Failure in Apoptotic Cell Clearance If clearance is impaired, apoptotic cells can undergo secondary necrosis and cause the release of pro-inflammatory cytokines by phagocytes Multiple studies support a direct link between a failure of apoptotic cell clearance and the development of the chr