肟基取代胆甾硫酸酯钠的合成.docVIP

肟基取代胆甾硫酸酯钠的合成在研究中我们发现，3，6-[1-3]。这里，我们合成了在甾核的3，6-位中同时存在肟基和硫酸酯钠基的化合物1-3，研究了它们对卵巢癌（Hey-1B）细胞株的细胞毒性，结果发现化合物2 对该肿瘤细胞株的抑制活性IC50值为44 nmol/mL。 1 2 3 关键词：胆甾醇；；合成参考文献: Jian-Guo Cui, Lei Fan, Li-Liang Huang, Hong-Li Liu, Ai-Min Zhou. Steroids，2009, 74 1 , 62-72 Jianguo Cui, Hui Wang, Yanmin Huang, Aimin Zhou, Steroids. 2009, 74 13-14 , 1057–1060 [3] Jianguo Cui, Lei Fan, Yanmin Huang, Yi Xin, Aimin Zhou, Steroids. 2009, 74 12 , 989-995 The synthesis of sodium cholesterol sulphate substituted by hydroxyimino Yan-Min Huang, Ying Li, Chunfang Gan, Jianguo Cui School of Chemistry and Life Science, Guangxi Teachers Education University, 530001, Nanning Our researches indicate that 3,6-dihydroxycholesterol disulfates and 3,6-dihydroxy- iminocholestane have a very good cytotoxicity[1-3]. Compounds 1-3 which 3,6-positions were substituted by hydroxyimino、sodium sulphate were synthesised. The cytotoxicity of the synthesized compounds against Hey-1B were investigated indicates that the antiproliferative activity IC50 value of 2 against Hey-1B is 44 nmol/mL.