术前静注维拉帕对腹腔镜胆囊切除术病人氧化应激反应的影响.doc

术前静注维拉帕米对腹腔镜胆囊切除术病人氧化应激反应的影响 518020 【摘要】目的 ?评价术前静注维拉帕米对腹腔镜胆囊切除术病人氧化应激反应的影响。方法：患慢性胆囊炎合并胆囊结石炎症急性发作行择期腹腔镜胆囊切除术（LC）的病人30例，年龄18-50岁，ASA分级Ⅰ～Ⅱ级患者，随机分为对照组（C组）和维拉帕米组（V组），每组15例。除维拉帕米组于气腹前10分钟静脉注射维拉帕米5毫克外，两组麻醉，气腹和手术方式均相近。两组病人分别于手术前，手术气腹结束即刻及术后24h抽静脉血标本，测定血清酶ALT,AST和脂质过氧化代谢产物MDA浓度。结果：与术前比较，C组和V组之ALT和AST值在术后放气即刻及术后24小时两个时间点均有显著增高（P〈0.05 ）,其中V组增高程度明显低于C组（P〈0.01）；V组之MDA值在术后放气即刻及术后24小时两个时间点无明显增高（P〉0.05 ）,两组比较V组明显低于C组（P〈0.01）。结论：术前静注抗氧化剂维拉帕米能有效减小气腹带来的氧化应激反应，有效保护肝脏等内脏功能。 【关键词】腹腔镜；氧化应激；维拉帕米 Preoperative static note verapamil of laparoscopic cholecystectomy patient oxidatie stress influence the reaction Wang Yu mei Shi Bi ming Department of Anesthesiology, Shenzhen City People’s Hospital ,Shenzhen 518020, China [Abstract] Objective To evaluation preoperative static note verapamil of laparoscopic cholecystectomy patient oxidatie stress influence the reaction. Methods: with chronic cholecystitis merger cystic and calculous inflammation acute onset of line elective laparoscopic cholecystectomy (LC) of patients, the age 18-30 cases of 50, ASA Ⅰ ~ Ⅱ level classification, randomized patients in control group (group C) and verapamil group (V group), each group 15 cases. Except verapamil group in gasless 10 minutes before the intravenous verapamil 5 mg outside, two groups of anesthesia, gasless and surgery entail near. Two groups of patients respectively on before surgery, surgery gasless end immediately and postoperative 24h smoke venous blood serum ALT specimen, determination of enzyme, AST and lipid peroxidation metabolites MDA concentration. Results: compared with the preoperative group C and V of ALT and AST value in the postoperative rt gas instantly and postoperative 24 hours two time points were significantly increased (P 0.05), including V group increased significantly lower group C (P 0.01), V group MDA value in the postoperative rt gas instantly and postoperative 24 hours two time points without significantly higher (P 0.05), two groups of comparisons V group significantl