利用SAPPHIRe 家族资料所做的相关性研究.doc

英文摘要 THE NEGATIVE CORRELATION BETWEEN PLASMA ADIPONECTIN AND BLOOD PRESSURE DEPENDS ON OBESITY: A FAMILY-BASED ASSOCIATION STUDY IN SAPPHIRe 1,2H-Y Li, 3Y-F Chiu, 4C-M Hwu, 5W H-H Sheu, 6Y-J Hung, 7W Fujimoto, 8T Quertermous, 7J. D Curb, 1T-Y Tai and 1,2,9L-M Chuang. 1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 2Graduate Institute of Clinical Medicine, Medical College, National Taiwan University, Taipei, Taiwan; 3Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taipei, Taiwan; 4Department of Medicine, Taipei Veterans General?Hospital and National Yang-Ming University, Taipei, Taiwan; 5Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan; 6Department of Medicine, Tri-Service General Hospital, Taiwan; 7Pacific Health Research Institute, Honolulu, HI, USA; 8Stanford University School of Medicine, Stanford, CA, USA; 9Graduate Institute of Preventive Medicine, National Taiwan University School of Public Health, Taipei, Taiwan BACKGROUND The association between plasma adiponectin level and blood pressure remains inconclusive. Because obese subjects may have different mechanisms to regulate blood pressure, we hypothesized that obesity may be an important modifier. In order to minimize confounding effects from unidentified factors, a family-based design was employed to explore the relationship. METHODS A total of 1,048 subjects from 478 Chinese or Japanese families with a mean age of 50.4 ± 9.0 years were included the SAPPHIRe Stanford-Asian Pacific Program in Hypertension and Insulin Resistance cohort . Blood pressure was recorded automatically and the average of the last two out of three consecutive readings was used in the analysis. A subject with “hypertension” was defined as one with a systolic blood pressure SBP ≥140 mm Hg, or a diastolic blood pressure DBP ≥90 mm Hg, or who was already on medication for hypertension. Obesity was defined as havi