MHC_and_Ag_presentation_II.pptVIP

Xiao-Ping Chen PhD 2010 Major Histocompatibility Complex: MHC MHC restriction 1996 Nobel prize winner MHC restriction The MHC type on APC has to be the same as the MHC on helped T cells — called self MHC restriction—a very selfish system (Ir gene) CD4 T cells------Class II restricted, CD8 T cells-------Class I restricted All these relate to one fact that MHC-peptide is the ligand for TCR The cells responsible for Ag processing are called antigen-presenting cell (APC) Theoretically, cells can be APC if they can a. take up antigens b. cleave big molecules into small peptides c. associ