无症状脑梗死认知障碍与血尿酸, 白细胞介素-6 的相关性.docVIP

无症状脑梗死认知障碍与血尿酸、白细胞介素-6的相关性 徐 磊 高春岭 刘玉洁 魏江山 谭 华（646000 四川泸州 泸州医学院附属医院神经内科） [摘要] 目的 探讨无症状脑梗死（SCI）患者认知障碍的发生率及其与血尿酸（UA）、白细胞介素-6（IL-6）的相关性。方法 连续收集我院SCI患者98例，采用中文版蒙特利尔认知量表MoCA）进行评分，将其分为认知障碍组及非认知障碍组，比较两组间UA、IL-6及其它相关因素的差异，将具有统计学意义的因素进入多因素分析，采用二分类非条件Logistic回归分析研究各因素对结果的影响。结果 本组SCI认知障碍发生率为59.2%（58例）。认知障碍组中男性比例较高，受教育年限较低，具有较高的甘油三酯（TG）、UA及IL-6。多因素Logistic回归分析表明教育年限（OR：0.222，95%.076～0.647，P=0.006），UA（OR：1.068，95%CI：1.013～1.126，P=0.015），IL-6（OR：1.803，95%CI：1.103～2.945，P=0.019）与认知障碍相关。结论 SCI患者具有较高的认知障碍发生率，教育年限越低，UA及IL-6越高可能是SCI患者认知障碍的危险因素。 [关键词] 无症状脑梗死；认知障碍；UA；IL-6 [中图分类号] R743.9 [文献标志码] A Uric acid and Interleukin-6 as predictors of cognitive impairment in silent cerebral infarction Xu Lei，Gao Chunling，Liu Yujie，Wei Jiangshan，Tan Hua1(Department of neurology, the Affiliated Hospital of Luzhou Medical College, Luzhou City, Sichuan Province 646000) [Abstract] Objective To investigate the incidence of cognitive impairment and its corelation with uric acid(UA) and interleukin-6(IL-6) in patients with silence cerebral infarction(SCI). Methods A total of 98 consecutive patients with SCI were selected in clinical practice. we carried on grading to all the patients with MoCA, then divided them into two groups-cognitive impairment group and normal cognitive group. Differences in the UA, IL-6 and other related factors were compared between the two groups, and analysis the statistically significant factots by using nonconditional Logistic regression to investigate the relationship between the various factors and results.Results the incidence of cognitive impairment among all the 98 patients was 59.2%(58 cases), males more than females, and it was related with low educated-years, high triglyceride(TG), UA and IL-6 level. The multiple logistic regression analysis showed that educated-years(OR：0.222，95%CI：0.076～0.647，P=0.006), UA(OR：1.068，95%CI：1.013～1.126，P=0.015), IL-6(OR：1.803，95%CI：1.103～2.945，P=0.019) were associated with cognitive impairment. Conclusion The cognitive impairmen